Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.10 extracted from

  • Bhatia, M.B.; Grubmeyer, C.
    The role of divalent magnesium in activating the reaction catalyzed by orotate phosphoribosyltransferase (1993), Arch. Biochem. Biophys., 303, 321-325.
    View publication on PubMed
Search for more literature for 2.4.2.10

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.027 0.0275 Orotate
-
 Salmonella enterica subsp. enterica serovar Typhimurium
0.044
-
 5-phospho-alpha-D-ribose 1-diphosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium
0.19
-
 Orotate methylester
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.63
-
 Uracil
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement Salmonella enterica subsp. enterica serovar Typhimurium
Mg2+ mechanism Salmonella enterica subsp. enterica serovar Typhimurium
Mg2+ no orotate-Mg-complex formation, weak Mg-enzyme-complex Salmonella enterica subsp. enterica serovar Typhimurium
Mg2+ best with 2 mM Salmonella enterica subsp. enterica serovar Typhimurium
Mn2+ can replace Mg2+ Salmonella enterica subsp. enterica serovar Typhimurium
Mn2+ activation Salmonella enterica subsp. enterica serovar Typhimurium
Mn2+ mechanism Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium orotidine 5'-phosphate + diphosphate
-
 ?
orotate methylester + phosphoribose diphosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + orotidine 4-methylester
-
 ?
uracil + phosphoribose diphosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + uridine
-
 ?