Application | Comment | Organism |
---|---|---|
medicine | endogenous PNP deficiency leads to specific T-cell immunodeficiency, a genetic disease. PNP inhibition leads to the elevation of 2'-deoxyguanosine levels and accumulation of intracellular deoxyguanosine 5'-triphosphate, inducing cellular apoptosis. Forodesine is a highly potent, orally active, rationally designed PNP inhibitor that is active in preclinical studies with malignant cells and clinical utility against T-cell acute lymphoblastic leukemia and cutaneous T-cell lymphoma | Homo sapiens |
medicine | purine nucleoside phosphorylase inhibition is a novel therapeutic approach for B-cell lymphoid malignancies | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
forodesine | a highly potent, orally active, rationally designed PNP inhibitor, that is active in preclinical studies with malignant cells and clinical utility against T-cell acute lymphoblastic leukemia and cutaneous T-cell lymphoma; a highly potent, orally active, rationally designed PNP inhibitor, use for the management of some B-cell malignancies | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-deoxyguanosine + phosphate | Homo sapiens | - |
guanine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-deoxyguanosine + phosphate | - |
Homo sapiens | guanine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PNP | - |
Homo sapiens |