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Literature summary for 2.4.2.1 extracted from

  • Stoychev, G.; Kierdaszuk, B.; Shugar, D.
    Xanthosine and xanthine. Substrate properties with purine nucleoside phosphorylases, and relevance to other enzyme systems (2002), Eur. J. Biochem., 269, 4048-4057.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
guanine inhibits phosphorolysis of xanthosine Bos taurus
guanine inhibits phosphorolysis of xanthosine Homo sapiens
guanosine inhibits phosphorolysis of xynthosine Bos taurus
guanosine inhibits phosphorolysis of xynthosine Homo sapiens
hypoxanthine inhibits phosphorolysis of xanthosine Bos taurus
hypoxanthine inhibits phosphorolysis of xanthosine Homo sapiens
xanthine poor inhibitor of phosphorolysis of guanosine Bos taurus
xanthine poor inhibitor of phosphorolysis of guanosine Homo sapiens
Xanthosine poor inhibitor of phosphorolysis of guanosine Bos taurus
Xanthosine poor inhibitor of phosphorolysis of guanosine Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.006
-
guanine pH 7.0 Homo sapiens
0.009
-
guanine pH 7.5 Homo sapiens
0.011
-
guanosine pH 7.0 Bos taurus
0.011
-
guanine pH 6.0 Bos taurus
0.012
-
guanosine pH 7.0 Homo sapiens
0.0138
-
guanine pH 7.0 Homo sapiens
0.014
-
guanosine pH 6.5 Homo sapiens
0.0159
-
guanosine pH 6.5 Bos taurus
0.022
-
guanine pH 7.5 Homo sapiens
0.029
-
guanine pH 6.0 Homo sapiens
0.046
-
guanosine pH 5.7 Bos taurus
0.091
-
guanosine pH 5.7 Homo sapiens
0.28
-
xanthine pH 6.0 Bos taurus
0.306
-
xanthine pH 7.5 Bos taurus
0.38
-
xanthine pH 6.0 Homo sapiens
0.4
-
Xanthosine pH 5.7 Bos taurus
0.425
-
xanthine pH 7.0 Homo sapiens
0.58
-
Xanthosine pH 5.7 Homo sapiens
1.1
-
Xanthosine pH 6.5 Bos taurus
1.6
-
Xanthosine pH 6.5 Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus P55859
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-
spleen
-
Homo sapiens
-
spleen
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-thioxanthine + alpha-D-ribose 1-phosphate
-
Homo sapiens 6-thioxanthosine + phosphate
-
?
6-thioxanthine + alpha-D-ribose 1-phosphate
-
Bos taurus 6-thioxanthosine + phosphate
-
?
guanosine + phosphate
-
Homo sapiens guanine + alpha-D-ribose 1-phosphate
-
r
guanosine + phosphate
-
Bos taurus guanine + alpha-D-ribose 1-phosphate
-
r
inosine + phosphate
-
Homo sapiens hypoxanthine + alpha-D-ribose 1-phosphate
-
r
inosine + phosphate
-
Bos taurus hypoxanthine + alpha-D-ribose 1-phosphate
-
r
xanthosine + arsenate
-
Homo sapiens xanthine + alpha-D-ribose 1-arsenate
-
?
xanthosine + arsenate
-
Bos taurus xanthine + alpha-D-ribose 1-arsenate
-
?
xanthosine + phosphate
-
Homo sapiens alpha-D-ribose 1-phosphate + xanthine
-
r
xanthosine + phosphate
-
Bos taurus alpha-D-ribose 1-phosphate + xanthine
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 6 reaction with xanthine or xanthosine Homo sapiens
5 6 reaction with xanthine or xanthosine Bos taurus
7 8 reaction with guanine, guanosine, hypoxanthine and inosine Homo sapiens
7 8 reaction with guanine, guanosine, hypoxanthine and inosine Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.004
-
guanine inhibition of phosphorolysis of xanthosine Homo sapiens
0.007
-
hypoxanthine inhibition of phosphorolysis of xanthosine Homo sapiens
0.01
-
guanosine inhibition of phosphorolysis of xanthosine Homo sapiens