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Literature summary for 2.4.2.1 extracted from

  • Kulikowska, E.; Bzowska, A.; Wierzchowski, J.; Shugar, D.
    Properties of two unusual, and fluorescent, substrates of purine-nucleoside phosphorylase: 7-methylguanosine and 7-methylinosine (1986), Biochim. Biophys. Acta, 874, 355-363.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine
-
Bos taurus
9-(1,3-dihydroxy-2-propoxymethyl)guanine
-
Bos taurus
9-(2-hydroxyethoxymethyl)guanine
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
Inosine
-
Bos taurus
0.015
-
7-methylguanosine
-
Bos taurus
0.6
-
7-Methylinosine
-
Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-methylguanosine + phosphate
-
Bos taurus 7-methylguanine + alpha-D-ribose 1-phosphate
-
?
7-methylinosine + phosphate
-
Bos taurus 7-methylhypoxanthine + alpha-D-ribose 1-phosphate
-
?
inosine + phosphate
-
Bos taurus hypoxanthine + alpha-D-ribose 1-phosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8.5
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0021
-
1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine reaction with 7-methylguanosine Bos taurus
0.0062
-
1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine reaction with inosine Bos taurus
0.024
-
9-(1,3-dihydroxy-2-propoxymethyl)guanine reaction with 7-methylguanosine Bos taurus
0.027
-
9-(1,3-dihydroxy-2-propoxymethyl)guanine reaction with inosine Bos taurus
0.058
-
9-(2-hydroxyethoxymethyl)guanine reaction with 7-methylguanosine Bos taurus
0.068
-
9-(2-hydroxyethoxymethyl)guanine reaction with inosine Bos taurus