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Literature summary for 2.4.2.1 extracted from
- Purine nucleoside phosphorylase of the malarial parasite, Plasmodium lophurae (1985), J. Biol. Chem., 260, 4455-4460.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 8-aminoguanosine | - |
Plasmodium lophurae |  |
| Azaguanine | - |
Plasmodium lophurae | |
| formycin B | - |
Plasmodium lophurae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.032 | - |
Inosine | - |
Plasmodium lophurae | |
| 0.082 | - |
hypoxanthine | - |
Plasmodium lophurae | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 23900 | - |
5 * 23900, SDS-PAGE | Plasmodium lophurae |
| 121800 | - |
non-denaturing PAGE | Plasmodium lophurae |
| 128800 | - |
gel filtration | Plasmodium lophurae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium lophurae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Plasmodium lophurae |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 8.7 | - |
- |
Plasmodium lophurae |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 50 mM Tris-HCl, 10 mM 2-mercaptoethanol, pH 7.0, stable for several months | Plasmodium lophurae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanosine + phosphate | 2.3% of the activity with inosine | Plasmodium lophurae | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| inosine + phosphate | - |
Plasmodium lophurae | hypoxanthine + alpha-D-ribose 1-phosphate | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| pentamer | 5 * 23900, SDS-PAGE | Plasmodium lophurae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 7.5 | - |
Plasmodium lophurae |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00039 | - |
formycin B | - |
Plasmodium lophurae | |
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Release 2023.1 (January 2023)
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