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Literature summary for 2.4.1.B72 extracted from

  • Wang, L.W.; Leonhard-Melief, C.; Haltiwanger, R.S.; Apte, S.S.
    Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan (2009), J. Biol. Chem., 284, 30004-30015.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Cricetulus griseus protein C-mannosylation is the attachment of alpha-mannopyranose to tryptophan via a C-C linkage. This post-translational modification typically occurs within the sequence motif WXXW, which is frequently present in thrombospondin type-1 repeats (TSRs). TSRs are especially numerous in and a defining feature of the ADAMTS superfamily. Predicted C-mannosylation sites in the ADAMTS superfamily, overview ?
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Organism

Organism UniProt Comment Textmining
Cricetulus griseus
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Source Tissue

Source Tissue Comment Organism Textmining
CHO-K1 cell
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 Cricetulus griseus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dolichyl D-mannosyl phosphate + ADAMTS-like 1 purified recombinant tagged substrate. The substrate contains in thrombospondin type-1 repeats, two with predicted C-mannosylation sites, C-mannosylation of TSR1 Cricetulus griseus dolichyl phosphate + C-mannosylated ADAMTS-like 1
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dolichyl D-mannosyl phosphate + human punctin-1 purified recombinant tagged substrate. C-mannosylation at Trp39 and Trp42 of a thrombospondin type-1 repeat containing the 36WDAWGPWSECSRTC49 sequence, identified by Tandem mass spectrometry (MS/MS) and MS/MS/MS analysis, TSR1 from punctin-1 carries C-mannosylation in close proximity to O-linked fucose Cricetulus griseus dolichyl phosphate + C-mannosylated human punctin-1
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additional information protein C-mannosylation is the attachment of alpha-mannopyranose to tryptophan via a C-C linkage. This post-translational modification typically occurs within the sequence motif WXXW, which is frequently present in thrombospondin type-1 repeats (TSRs). TSRs are especially numerous in and a defining feature of the ADAMTS superfamily. Predicted C-mannosylation sites in the ADAMTS superfamily, overview Cricetulus griseus ?
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additional information analysis of C-mannosylation sites an substrate recognition, mutational analysis, mass spectroscopy, and metabolic labeling, overview Cricetulus griseus ?
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General Information

General Information Comment Organism
malfunction no activity in CHO cell mutant cells Lec35.1 Cricetulus griseus
physiological function the enzyme catalyzes post-trans­lational modification of thrombospondin type-1 repeats in ADAMTS-like and punctin-1 by C-mannosylation of tryptophan Cricetulus griseus