Organism | UniProt | Comment | Textmining |
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Paeniclostridium sordellii | V5T923 | - |
- |
General Information | Comment | Organism |
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physiological function | isoform TcsL enters target cells via receptor-mediated endocytosis and delivers the N-terminal catalytic domain (TcsL-cat) into the cytosol. TcsL-cat binds to brain phosphatidylserine-containing membranes and to phosphatidic acid and, to a lesser extent, to other anionic lipids, but not to neutral lipids, sphingolipids or sterol. The lipid unsaturation status influences TcsL-cat binding to phospholipids, phosphatidylserines with unsaturated acyl chains and phosphatidic acids with saturated acyl chains being the preferred binding substrates. The phospholipid binding site is localized at the N-terminal four helical bundle structure (1-93 domain). Recombinant TcsL-1-93 binds to a broad range of substrates, whereas TcsL-cat, which is the active domain physiologically delivered into the cytosol, selectively binds to phosphatidylserine and phosphatidic acid | Paeniclostridium sordellii |