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Literature summary for 2.4.1.B62 extracted from

  • Just, I.; Wilm, M.; Selzer, J.; Rex, G.; von Eichel-Streiber, C.; Mann, M.; Aktories, K.
    The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins (1995), J. Biol. Chem., 270, 13932-13936.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Clostridioides difficile P16154 toxin A
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information in the absence of target proteins toxin A acts as hydrolase cleaving UDP-D-glucose to UDP and D-glucose Clostridioides difficile ?
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?
additional information UDP-alpha-D-glucose selectively serves as cosubstrate for toxin A-catalyzed modification. The acceptor amino acid of glucosylation is Thr37. Mutation of Thr37 to Ala completely abolishes glucosylation. No substrates: H-Ras, Rab5, and Arf1 Clostridioides difficile ?
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UDP-alpha-D-glucose + Cdc42Hs
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Clostridioides difficile UDP + D-glucosyl-Cdc42Hs
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UDP-alpha-D-glucose + Rac1
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Clostridioides difficile UDP + D-glucosyl-Rac1
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UDP-alpha-D-glucose + RhoA
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Clostridioides difficile UDP + D-glucosyl-RhoA
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?