Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridioides difficile | P16154 | toxin A | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | in the absence of target proteins toxin A acts as hydrolase cleaving UDP-D-glucose to UDP and D-glucose | Clostridioides difficile | ? | - |
? | |
additional information | UDP-alpha-D-glucose selectively serves as cosubstrate for toxin A-catalyzed modification. The acceptor amino acid of glucosylation is Thr37. Mutation of Thr37 to Ala completely abolishes glucosylation. No substrates: H-Ras, Rab5, and Arf1 | Clostridioides difficile | ? | - |
? | |
UDP-alpha-D-glucose + Cdc42Hs | - |
Clostridioides difficile | UDP + D-glucosyl-Cdc42Hs | - |
? | |
UDP-alpha-D-glucose + Rac1 | - |
Clostridioides difficile | UDP + D-glucosyl-Rac1 | - |
? | |
UDP-alpha-D-glucose + RhoA | - |
Clostridioides difficile | UDP + D-glucosyl-RhoA | - |
? |