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Literature summary for 2.4.1.92 extracted from

  • Yusuf, H.K.M.; Schwarzmann, G.; Pohlentz, G.; Sandhoff, K.
    Oligosialogangliosides inhibit GM2- and GD3-synthesis in isolated Golgi vesicles from rat liver (1987), Biol. Chem. Hoppe-Seyler, 368, 455-462.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
Detergents requirement, solubilized enzyme, e.g. Triton X-100 Rattus norvegicus
octylglucoside activation Rattus norvegicus
phosphatidylglycerol activation, detergent-free assay Rattus norvegicus
Triton X-100
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ganglioside GD1a
-
 Rattus norvegicus
ganglioside GM1
-
 Rattus norvegicus
ganglioside GM2
-
 Rattus norvegicus
ganglioside GQ1b not in detergent-solubilized enzyme assays, kinetics Rattus norvegicus
ganglioside GT1b
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Rattus norvegicus 5794
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
-
 Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide i.e. GM2(N-acetylneuraminic acid)-ganglioside ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus