Literature summary for 2.4.1.90 extracted from

Chang, H.H.; Chen, C.H.; Chou, C.H.; Liao, Y.F.; Huang, M.J.; Chen, Y.H.; Wang, W.J.; Huang, J.; Hung, J.S.; Ho, W.L.; Jeng, Y.M.; Che, M.I.; Lee, H.; Lu, M.Y.; Yang, Y.L.; Jou, S.T.; Lin, D.T.; Lin, K.H.; Hsu, W.M.; Huang, M.C.
beta-1,4-Galactosyltransferase III enhances invasive phenotypes via beta1-integrin and predicts poor prognosis in neuroblastoma (2013), Clin. Cancer Res., 19, 1705-1716.

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Application

Application	Comment	Organism
medicine	enzyme expression is an independent prognostic factor for poor survival of neuroblastoma patients	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-alpha-D-galactose + N-acetyl-D-glucosamine	Homo sapiens	-	UDP + N-acetyllactosamine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15291	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuroblastoma cell	-	Homo sapiens	-
SH-SY5Y cell	-	Homo sapiens	-
SK-N-DZ cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-alpha-D-galactose + N-acetyl-D-glucosamine	-	Homo sapiens	UDP + N-acetyllactosamine	-	?

Synonyms

Synonyms	Comment	Organism
B4GALT3	-	Homo sapiens
beta-1,4-galactosyltransferase III	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	enzyme overexpression increases migration, invasion, and tumor growth of neuroblastoma cells, increases lactosamine glycans on beta1-integrin, increases expression of mature beta1-integrin via delayed degradation, and enhances phosphorylation of focal adhesion kinase	Homo sapiens

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Release 2023.1 (January 2023)