Activating Compound | Comment | Organism | Structure |
---|---|---|---|
alpha-lactalbumin | alters the substrate specificity of EC 2.4.1.38 to EC 2.4.1.90, and leads to complex formation with the enzyme as lactose synthase, EC 2.4.1.22 | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetone | 20% v/v, 37% inhibition | Bos taurus | |
acetonitrile | 20% v/v, complete inhibition | Bos taurus | |
alpha-lactalbumin | - |
Bos taurus | |
Dimethylsulfoxide | 20% v/v, 62% inhibition | Bos taurus | |
ethanol | 20% v/v, 42% inhibition | Bos taurus | |
N,N-Dimethylformamide | 20% v/v, 84% inhibition | Bos taurus | |
N-methylpyrrolidone | 20% v/v, 9% inhibition | Bos taurus | |
tetrahydrofuran | 20% v/v, complete inhibition | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Bos taurus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | - |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-galactose + N-acetylglucosamine | Bos taurus | - |
UDP + N-acetyllactosamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
milk | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | substrate specificity in presence or absence of alpha-lactalbumin, overview, the 'specifier' protein alpha-lactalbumin, which interacts with beta-1,4-GalT forming the lactose synthase complex, EC 2.4.1.22, is not necessary when the acceptors are different glucopyranosides, EC 2.4.1.38, and, in some cases, it can even have an inhibitory effect, e.g. in reaction with the complex glucosides ginsenoside Rg1 and colchicoside, overview | Bos taurus | ? | - |
? | |
UDP-galactose + colchicoside | - |
Bos taurus | ? | - |
? | |
UDP-galactose + D-glucose | reaction of EC 2.4.1.22 | Bos taurus | UDP + lactose | - |
? | |
UDP-galactose + ginsenoside Rg1 | - |
Bos taurus | ? | - |
? | |
UDP-galactose + N-acetyl-D-glucosamine | in presence of alpha-lactalbumin, the enzyme catalyzes reaction of EC 2.4.1.22 | Bos taurus | UDP + N-acetyllactosamine | - |
? | |
UDP-galactose + N-acetylglucosamine | - |
Bos taurus | UDP + N-acetyllactosamine | - |
? | |
UDP-galactose + N-acetylglucosamine | partial reaction of EC 2.4.1.22 | Bos taurus | UDP + N-acetyllactosamine | - |
? | |
UDP-glucose + colchicoside | - |
Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-1,4-galactosyltransferase | - |
Bos taurus |
beta-1,4-GalT | - |
Bos taurus |
More | cf. EC 2.4.1.38 and 2.4.1.22 | Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.4 | - |
assay at | Bos taurus |