Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.90 extracted from

  • Pisvejcova, A.; Rossi, C.; Husakova, L.; Kren, V.; Riva, S.; Monti, D.
    beta-1,4-Galactosyltransferase-catalyzed glycosylation of sugar derivatives: Modulation of the enzyme activity by alpha-lactalbumin, immobilization and solvent tolerance (2006), J. Mol. Catal. B, 39, 98-104.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
alpha-lactalbumin alters the substrate specificity of EC 2.4.1.38 to EC 2.4.1.90, and leads to complex formation with the enzyme as lactose synthase, EC 2.4.1.22 Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
acetone 20% v/v, 37% inhibition Bos taurus
acetonitrile 20% v/v, complete inhibition Bos taurus
alpha-lactalbumin
-
Bos taurus
Dimethylsulfoxide 20% v/v, 62% inhibition Bos taurus
ethanol 20% v/v, 42% inhibition Bos taurus
N,N-Dimethylformamide 20% v/v, 84% inhibition Bos taurus
N-methylpyrrolidone 20% v/v, 9% inhibition Bos taurus
tetrahydrofuran 20% v/v, complete inhibition Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Bos taurus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-galactose + N-acetylglucosamine Bos taurus
-
UDP + N-acetyllactosamine
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
milk
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information substrate specificity in presence or absence of alpha-lactalbumin, overview, the 'specifier' protein alpha-lactalbumin, which interacts with beta-1,4-GalT forming the lactose synthase complex, EC 2.4.1.22, is not necessary when the acceptors are different glucopyranosides, EC 2.4.1.38, and, in some cases, it can even have an inhibitory effect, e.g. in reaction with the complex glucosides ginsenoside Rg1 and colchicoside, overview Bos taurus ?
-
?
UDP-galactose + colchicoside
-
Bos taurus ?
-
?
UDP-galactose + D-glucose reaction of EC 2.4.1.22 Bos taurus UDP + lactose
-
?
UDP-galactose + ginsenoside Rg1
-
Bos taurus ?
-
?
UDP-galactose + N-acetyl-D-glucosamine in presence of alpha-lactalbumin, the enzyme catalyzes reaction of EC 2.4.1.22 Bos taurus UDP + N-acetyllactosamine
-
?
UDP-galactose + N-acetylglucosamine
-
Bos taurus UDP + N-acetyllactosamine
-
?
UDP-galactose + N-acetylglucosamine partial reaction of EC 2.4.1.22 Bos taurus UDP + N-acetyllactosamine
-
?
UDP-glucose + colchicoside
-
Bos taurus ?
-
?

Synonyms

Synonyms Comment Organism
beta-1,4-galactosyltransferase
-
Bos taurus
beta-1,4-GalT
-
Bos taurus
More cf. EC 2.4.1.38 and 2.4.1.22 Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.4
-
assay at Bos taurus