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Literature summary for 2.4.1.88 extracted from

  • Ishibashi, T.; Ohkubo, I.; Makita, A.
    Solubilization and partial characterization of UDP-N-acetylgalactosamine: globoside alpha-N-acetylgalactosaminyltransferase from dog spleen microsomes (1977), Biochim. Biophys. Acta, 484, 24-34.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
diphosphatidylglycerol activation Canis lupus familiaris
GSH slight stimulation Canis lupus familiaris
additional information requirement for phospholipids Canis lupus familiaris
phosphatidic acid activation Canis lupus familiaris
phosphatidylcholine activation Canis lupus familiaris
phosphatidylethanolamine activation Canis lupus familiaris
phosphatidylinositol activation Canis lupus familiaris
phosphatidylserine activation Canis lupus familiaris
sphingomyelin activation Canis lupus familiaris
Triton X-100 activation Canis lupus familiaris
Triton X-100 best at 0.3-0.6% Canis lupus familiaris

General Stability

General Stability Organism
phosphatidylserine stabilizes Canis lupus familiaris

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
Canis lupus familiaris
ATP
-
Canis lupus familiaris
CDP
-
Canis lupus familiaris
EDTA strong Canis lupus familiaris
GDP
-
Canis lupus familiaris
IDP
-
Canis lupus familiaris
additional information no inhibitor: NaF Canis lupus familiaris
NaN3 weak Canis lupus familiaris
PCMB over 90% inhibition at 2 mM Canis lupus familiaris
UDP 85% inhibition at 1.5 mM Canis lupus familiaris
uridine weak Canis lupus familiaris

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
UDP-N-acetylgalactosamine
-
Canis lupus familiaris
0.5
-
globoside
-
Canis lupus familiaris

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Canis lupus familiaris 16020
-
microsome
-
Canis lupus familiaris
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ no effect Canis lupus familiaris
Mn2+ optimal concentration: 10 mM Canis lupus familiaris
Mn2+ absolute requirement, cannot be replaced by Ca2+ and Mg2+ Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide Canis lupus familiaris involved in biosynthesis of carbohydrate moiety of sphingoglycolipids UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide i.e. Forssman hapten ?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
mongrel dog, adult
-

Purification (Commentary)

Purification (Comment) Organism
partial Canis lupus familiaris

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
Canis lupus familiaris
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Canis lupus familiaris

Storage Stability

Storage Stability Organism
-20°C, at least 2 weeks without loss of activity Canis lupus familiaris

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + globoside
-
Canis lupus familiaris UDP + N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide
-
?
UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide
-
Canis lupus familiaris UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide i.e. Forssman hapten ?
UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide involved in biosynthesis of carbohydrate moiety of sphingoglycolipids Canis lupus familiaris UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide i.e. Forssman hapten ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Canis lupus familiaris

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.6
-
-
Canis lupus familiaris