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Literature summary for 2.4.1.80 extracted from

  • Gupta, V.; Bhinge, K.N.; Hosain, S.B.; Xiong, K.; Gu, X.; Shi, R.; Ho, M.Y.; Khoo, K.H.; Li, S.C.; Li, Y.T.; Ambudkar, S.V.; Jazwinski, S.M.; Liu, Y.Y.
    Ceramide glycosylation by glucosylceramide synthase selectively maintains the properties of breast cancer stem cells (2012), J. Biol. Chem., 287, 37195-37205.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
1-phenyl-2-decanoylamino-3-morpholino-1-propanol
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
GCS
-
 Homo sapiens
glucosylceramide synthase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens glucosylceramide synthase expression is enhanced in breast cancer stem cells but not in normal mammary epithelial stem cells up

General Information

General Information Comment Organism
malfunction silencing glucosylceramide synthase expression disrupts Gb3 synthesis and selectively kills breast cancer stem cells through deactivation of c-Src/beta-catenin signaling Homo sapiens