Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-phenyl-2-decanoylamino-3-morpholino-1-propanol | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GCS | - |
Homo sapiens |
glucosylceramide synthase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | glucosylceramide synthase expression is enhanced in breast cancer stem cells but not in normal mammary epithelial stem cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | silencing glucosylceramide synthase expression disrupts Gb3 synthesis and selectively kills breast cancer stem cells through deactivation of c-Src/beta-catenin signaling | Homo sapiens |