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Literature summary for 2.4.1.80 extracted from

  • Haynes, T.A.; Filippov, V.; Filippova, M.; Yang, J.; Zhang, K.; Duerksen-Hughes, P.J.
    DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells (2012), Biochim. Biophys. Acta, 1821, 943-953.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
threo-1-phenyl-2-decanoyl-amino-3-morpholino-1-propanol inhibition at 0.005 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
U2-OS cell U2OS-AS cell, construction of the pHA-E6S and pHA-E6AS plasmids, which respectively contain either the sense or the antisense versions of epitope-tagged E6 (HA-E6) under the control of the CMV promoter, and establishment of the U2OSE64b and U2OSE6AS cell lines by stable transfection with these plasmids has been described previously Homo sapiens
-
U2-OS cell U2OS-E6b4 cell, construction of the pHA-E6S and pHA-E6AS plasmids, which respectively contain either the sense or the antisense versions of epitope-tagged E6 (HA-E6) under the control of the CMV promoter, and establishment of the U2OSE64b and U2OSE6AS cell lines by stable transfection with these plasmids has been described previously Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + ceramide
-
Homo sapiens UDP + glucosylceramide
-
?
UDP-glucose + N-acylsphingosine
-
Homo sapiens UDP + D-glucosyl-N-acylsphingosine
-
?

Synonyms

Synonyms Comment Organism
UDP-glucose ceramide glycosyltransferase
-
Homo sapiens
Ugcg
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens in the absence of p53, mitomycin C treatment elicits a down-regulation of the enzyme down

General Information

General Information Comment Organism
malfunction inhibiting UDP-glucose ceramide glycosyltransferase increases the susceptibility of p53-deficient cells, but not p53-expressing cells, to mitomycin C. Enzyme down-regulation contributes to the accumulation of ceramide in cells lacking p53 Homo sapiens