Inhibitors | Comment | Organism | Structure |
---|---|---|---|
threo-1-phenyl-2-decanoyl-amino-3-morpholino-1-propanol | inhibition at 0.005 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
U2-OS cell | U2OS-AS cell, construction of the pHA-E6S and pHA-E6AS plasmids, which respectively contain either the sense or the antisense versions of epitope-tagged E6 (HA-E6) under the control of the CMV promoter, and establishment of the U2OSE64b and U2OSE6AS cell lines by stable transfection with these plasmids has been described previously | Homo sapiens | - |
U2-OS cell | U2OS-E6b4 cell, construction of the pHA-E6S and pHA-E6AS plasmids, which respectively contain either the sense or the antisense versions of epitope-tagged E6 (HA-E6) under the control of the CMV promoter, and establishment of the U2OSE64b and U2OSE6AS cell lines by stable transfection with these plasmids has been described previously | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + ceramide | - |
Homo sapiens | UDP + glucosylceramide | - |
? | |
UDP-glucose + N-acylsphingosine | - |
Homo sapiens | UDP + D-glucosyl-N-acylsphingosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucose ceramide glycosyltransferase | - |
Homo sapiens |
Ugcg | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | in the absence of p53, mitomycin C treatment elicits a down-regulation of the enzyme | down |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibiting UDP-glucose ceramide glycosyltransferase increases the susceptibility of p53-deficient cells, but not p53-expressing cells, to mitomycin C. Enzyme down-regulation contributes to the accumulation of ceramide in cells lacking p53 | Homo sapiens |