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Literature summary for 2.4.1.80 extracted from

  • Wennekes, T.; Lang, B.; Leeman, M.; van der Marel, G.A.; Smits, E.; Weber, M.; van Wiltenburg, J.; Wolberg, M.; Aerts, J.M.; Overkleeft, H.S.
    Large-Scale Synthesis of the Glucosylceramide Synthase Inhibitor N-[5-(Adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin (2008), Org. Process Res. Dev., 12, 414-423.
No PubMed abstract available
Search for more literature for 2.4.1.80

Inhibitors

Inhibitors Comment Organism Structure
(1S)-1-C-[5-(adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin
-
 Homo sapiens
(1S)-N-butyl-1-C-[5-(adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin
-
 Homo sapiens
N-[5-(adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information NBD ceramide is used as substrate Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
glucosylceramide synthase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
-
 Homo sapiens N-[5-(adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin
0.009
-
-
 Homo sapiens (1S)-1-C-[5-(adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin
0.025
-
-
 Homo sapiens (1S)-N-butyl-1-C-[5-(adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin