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Literature summary for 2.4.1.80 extracted from

  • Itoh, M.; Kitano, T.; Watanabe, M.; Kondo, T.; Yabu, T.; Taguchi, Y.; Iwai, K.; Tashima, M.; Uchiyama, T.; Okazaki, T.
    Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia (2003), Clin. Cancer Res., 9, 415-423.
    View publication on PubMed
Search for more literature for 2.4.1.80

Cloned(Commentary)

Cloned (Comment) Organism
gene GluT-1 cloned from a human melanoma genetic library, transient overexpression in HL-60 and HL-60/ADR cells, induced resistance to DOX in HL-60 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
doxorubicin i.e. DOX; increases enzyme activity in drug-sensitive cell line HL-60, but not in drug-resistant HL-60/ADR cell line; regulation of intracellular ceramide is closely related to drug resistance and DOX-induced apoptosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucose + N-acylsphingosine Homo sapiens regulation of intracellular ceramide is closely related to drug resistance and DOX-induced apoptosis UDP + D-glucosyl-N-acylsphingosine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 gene GluT-1
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow of leukaemic patients before chemotherapy Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
leukemia cell line HL-60/ADR Homo sapiens
-
mononuclear cell
-
 Homo sapiens
-
peripheral blood peripheral blood cell of leukaemic patients before chemotherapy Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + N-acylsphingosine i.e. ceramide Homo sapiens UDP + D-glucosyl-N-acylsphingosine i.e. glucosylceramide ?
UDP-glucose + N-acylsphingosine regulation of intracellular ceramide is closely related to drug resistance and DOX-induced apoptosis Homo sapiens UDP + D-glucosyl-N-acylsphingosine
-
 ?

Synonyms

Synonyms Comment Organism
GCS
-
 Homo sapiens
GlcCer synthase
-
 Homo sapiens