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Literature summary for 2.4.1.69 extracted from

  • Mathieu, S.; Prorok, M.; Benoliel, A.M.; Uch, R.; Langlet, C.; Bongrand, P.; Gerolami, R.; El-Battari, A.
    Transgene expression of alpha(1,2)-fucosyltransferase-I (FUT1) in tumor cells selectively inhibits sialyl-lewis x expression and binding to E-selectin without affecting synthesis of sialyl-Lewis a or binding to P-selectin (2004), Am. J. Pathol., 164, 371-383.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine FUT1 can efficiently prevent the synthesis of slex antigens in hepatocarcinoma and colon carcinoma cells and their interaction with activated endothelia. The FUT-EGFP gene transfer approach would be expected to decrease or even suppress the initial vascular arrest of tumor cells and may provide a basis for the development of antimetastatic gene therapy Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens FUT1 is able to efficiently alpha(1,2)-fucosylate the O-linked glycans of PSGL-1 but not the sLex structures that bind too the P-selectin ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
BxPC-3 cell stable transfeceted with FUT1 cDNA in a pcDNA3 vector Homo sapiens
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Hep-G2 cell stable transfeceted with FUT1 cDNA in a pcDNA3 vector Homo sapiens
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HT-29 cell stable transfeceted with FUT1 cDNA in a pcDNA3 vector Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information FUT1 is able to efficiently alpha(1,2)-fucosylate the O-linked glycans of PSGL-1 but not the sLex structures that bind too the P-selectin Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
alpha(1,2)-fucosyltransferase-I
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 Homo sapiens
FUT1
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 Homo sapiens