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Literature summary for 2.4.1.69 extracted from

  • Bureau, V.; Marionneau, S.; Cailleau-Thomas, A.; Le Moullac-Vaidye, B.; Liehr, T.; Le Pendu, J.
    Comparison of the three rat GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferases FTA, FTB and FTC (2001), Eur. J. Biochem., 268, 1006-1019.
    View publication on PubMed
Search for more literature for 2.4.1.69

Cloned(Commentary)

Cloned (Comment) Organism
cloning of gene FTB and FTC Rattus norvegicus
transfection of Chinese hamster ovary cells Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.024
-
 GDP-L-fucose enzyme FTB Rattus norvegicus
0.024
-
 GDP-beta-L-fucose pH 7.2, 37°C Rattus norvegicus
0.068
-
 GDP-L-fucose enzyme FTA Rattus norvegicus
0.068
-
 GDP-beta-L-fucose pH 7.2, 37°C Rattus norvegicus
3.8
-
 galacto-N-biose enzyme FTB Rattus norvegicus
3.8
-
 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine pH 7.2, 37°C Rattus norvegicus
5.2
-
 N-acetyllactosamine enzyme FTA Rattus norvegicus
7.1
-
 lacto-N-biose enzyme FTA Rattus norvegicus
7.1
-
 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine pH 7.2, 37°C Rattus norvegicus
8.3
-
 lacto-N-biose enzyme FTB Rattus norvegicus
8.3
-
 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine pH 7.2, 37°C Rattus norvegicus
11.1
-
 galacto-N-biose enzyme FTA Rattus norvegicus
11.1
-
 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine pH 7.2, 37°C Rattus norvegicus
20
-
 N-acetyllactosamine enzyme FTB Rattus norvegicus
25
-
 phenyl beta-galactose enzyme FTB Rattus norvegicus
25
-
 phenyl beta-galactose enzyme FTA Rattus norvegicus
33
-
 phenyl beta-D-galactopyranoside pH 7.2, 37°C Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine Rattus norvegicus residues of H type 3 epitopes, reaction of EC 2.4.1.69 GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine
-
 ?
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine Rattus norvegicus residues of H type 1 epitopes, reaction of EC 2.4.1.69 GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine
-
 ?
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosamine Rattus norvegicus residues of H type 3 epitopes, reaction of EC 2.4.1.69 GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosamine
-
 ?
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine Rattus norvegicus residues of H type 2 epitopes GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
 ?
GDP-beta-L-fucose + phenyl beta-D-galactopyranoside Rattus norvegicus
-
 GDP + phenyl alpha-L-fucosyl-(1->2)-beta-D-galactopyranoside
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 three alpha1,2-fucosyltransferase genes: FTA, FTB and FTC
-
Rattus norvegicus Q10980
-
-
Rattus norvegicus Q10984
-
-

Source Tissue

Source Tissue Comment Organism Textmining
distal colon mRNA of FTA and FTC Rattus norvegicus
-
intestine small and large intestine Rattus norvegicus
-
intestine small and large intestines Rattus norvegicus
-
kidney mRNA of FTA and FTC Rattus norvegicus
-
liver mRNA of FTA and FTC Rattus norvegicus
-
lung mRNA of FTA and FTC Rattus norvegicus
-
lymph node mRNA of FTA and FTC Rattus norvegicus
-
additional information no cDNA detected in urinary bladder, the testis, the seminal vesicle, the ovary, the uterus, the spleen, the brain or muscle Rattus norvegicus
-
olfactory bulb
-
 Rattus norvegicus
-
proximal colon mRNA of FTA, FTB and FTC Rattus norvegicus
-
salivary gland
-
 Rattus norvegicus
-
skin
-
 Rattus norvegicus
-
small intestine mRNA of FTA, FTB and FTC Rattus norvegicus
-
stomach
-
 Rattus norvegicus
-
submaxillary gland FTA mRNA and FTC mRNA Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine residues of H type 3 epitopes, reaction of EC 2.4.1.69 Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine
-
 ?
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine residues of H type 3 epitopes Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine
-
 ?
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine residues of H type 1 epitopes, reaction of EC 2.4.1.69 Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine
-
 ?
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine residues of H type 1 epitopes Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine
-
 ?
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosamine residues of H type 3 epitopes, reaction of EC 2.4.1.69 Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosamine
-
 ?
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine residues of H type 2 epitopes Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
 ?
GDP-beta-L-fucose + lacto-N-biose
-
 Rattus norvegicus ?
-
 ?
GDP-beta-L-fucose + phenyl beta-D-galactopyranoside
-
 Rattus norvegicus GDP + phenyl alpha-L-fucosyl-(1->2)-beta-D-galactopyranoside
-
 ?
GDP-L-fucose + beta-D-galactosyl-R
-
 Rattus norvegicus GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
 ?
GDP-L-fucose + galacto-N-biose
-
 Rattus norvegicus GDP + alpha-L-fucosyl-1,2-galacto-N-biose
-
 ?
GDP-L-fucose + lacto-N-biose 1
-
 Rattus norvegicus GDP + L-Fucalpha(1-2)Galbeta(1-3)GlcNAc
-
 ?
GDP-L-fucose + N-acetyllactosamine
-
 Rattus norvegicus GDP + alpha-L-fucosyl-1,2-N-acetyllactosamine
-
 ?
GDP-L-fucose + phenyl-beta-D-galactoside
-
 Rattus norvegicus GDP + phenyl 2-O-(alpha-L-fucopyranosyl)-beta-D-galactopyranoside
-
 ?

Synonyms

Synonyms Comment Organism
FTA
-
 Rattus norvegicus
Ftb
-
 Rattus norvegicus
FUT1
-
 Rattus norvegicus
FUT2
-
 Rattus norvegicus
galactoside 2-alpha-L-fucosyltransferase 1
-
 Rattus norvegicus
galactoside 2-alpha-L-fucosyltransferase 2
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function isoform Fta allows synthesis of H type 2 and H type 3 histo-blood group antigen epitopes at the cell surface. In Chinese hamster ovary cells transfected by FTA, FTA is able to synthesize H type 2 epitopes on a large set of glycoproteins Rattus norvegicus