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Literature summary for 2.4.1.69 extracted from

  • Chandrasekaran, E.V.; Jain, R.K.; Larsen, R.D.; Wlasichuk, K.; Matta, K.L.
    Characterization of the specificities of human blood group H gene-specified alpha1,2-L-fucosyltransferase toward sulfated/sialylated/fucosylated acceptors: evidence for an inverse relationship between alpha1,2-L-fucosylation of Gal and alpha1,6-L-fucosylation of asparagine-linked GlcNAc (1996), Biochemistry, 35, 8914-8924.
    View publication on PubMed
Search for more literature for 2.4.1.69

Inhibitors

Inhibitors Comment Organism Structure
3-sulfoGalbeta(1,4)GlcNAcbeta(1,6)Galbeta(1,3)GalNAcalpha-O-benzyl
-
 Homo sapiens
Galbeta(1,3)GalNAcalpha-O-allyl
-
 Homo sapiens
Galbeta(1,4)GlcNAcbeta(1,6)3-sulfoGalbeta(1,3)-GalNAcalpha-O-benzyl
-
 Homo sapiens
Galbeta(1,4)GlcNAcbeta(1,6)Galbeta(1,3)-GalNAcalpha-O-benzyl
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.31
-
 Galbeta(1-3)GlcNAcbeta-O-allyl/acrylamide copolymer
-
 Homo sapiens
0.45
-
 6-sulfoGalbeta(1-4)GlcNAcbeta-O-methyl
-
 Homo sapiens
0.5
-
 fetuin triantennary asialoglycopeptide
-
 Homo sapiens
0.82
-
 Galbeta-O-benzyl
-
 Homo sapiens
0.83
-
 Galbeta(1-3)GlcNAcbeta-O-benzyl
-
 Homo sapiens
0.95
-
 GDP-L-fucose reaction with Galbeta(1-3)GalNAcalpha-O-allyl Homo sapiens
1
-
 bovine IgG diantennary glycopeptide
-
 Homo sapiens
1.33
-
 GDP-L-fucose reaction with Galbeta(1-3)GlcNAcbeta-O-allyl Homo sapiens
1.54
-
 GDP-L-fucose reaction with 6-sulfoGalbeta(1-3)GlcNAcbeta-O-allyl Homo sapiens
1.67
-
 Galbeta(1-4)GlcNAcbeta-O-benzyl
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinant and native enzyme
-

Source Tissue

Source Tissue Comment Organism Textmining
ovarian cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-L-fucose + 6-sulfoGalbeta(1-4)GlcNAcbeta-O-methyl
-
 Homo sapiens GDP + L-Fucalpha(1-2)6-sulfoGalbeta(1-4)GlcNAcbeta-O-methyl
-
 ?
GDP-L-fucose + beta-D-galactosyl-R detailed characterization of specificity Homo sapiens GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
 ?
GDP-L-fucose + bovine IgG diantennary glycopeptide
-
 Homo sapiens GDP + ?
-
 ?
GDP-L-fucose + fetuin triantennary asialoglycopeptide
-
 Homo sapiens GDP + ?
-
 ?
GDP-L-fucose + Galbeta(1-3)GlcNAcbeta-O-allyl/acrylamide copolymer
-
 Homo sapiens GDP + ?
-
 ?
GDP-L-fucose + Galbeta(1-3)GlcNAcbeta-O-benzyl
-
 Homo sapiens GDP + L-Fucalpha(1-2)Galbeta(1-3)GlcNAcbeta-O-benzyl
-
 ?
GDP-L-fucose + Galbeta(1-4)GlcNAcbeta-O-benzyl
-
 Homo sapiens GDP + L-Fucalpha(1-2)Galbeta(1-4)GlcNAcbeta-O-benzyl
-
 ?
GDP-L-fucose + Galbeta-O-benzyl
-
 Homo sapiens GDP + L-Fucalpha(1-2)Galbeta-O-benzyl
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 8 enzyme from ovarian tumor Homo sapiens
7.2 7.6 recombinant enzyme Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6 7.6 pH 6.0: 15% of maximal activity, pH 6.4: 59.2% of maximal activity, pH 6.8: 84.8% of maximal activity, pH 7.2-7.6: maximal activity, recombinant enzyme Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.6
-
 Galbeta(1,3)GalNAcalpha-O-allyl reaction with 6-sulfoGalbeta(1,3)GlcNAcbeta-O-allyl Homo sapiens
5.9
-
 Galbeta(1,4)GlcNAcbeta(1,6)Galbeta(1,3)-GalNAcalpha-O-benzyl reaction with 6-sulfoGalbeta(1,4)GlcNAcbeta-O-methyl Homo sapiens