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Literature summary for 2.4.1.68 extracted from

  • Matsumoto, K.; Yokote, H.; Arao, T.; Maegawa, M.; Tanaka, K.; Fujita, Y.; Shimizu, C.; Hanafusa, T.; Fujiwara, Y.; Nishio, K.
    N-Glycan fucosylation of epidermal growth factor receptor modulates receptor activity and sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor (2008), Cancer Sci., 99, 1611-1617.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information 293/EGFR/FUT8, HEK-293 cells transfected with epidermal growth factor receptor and FUT8, increased fucosylation of EGFR, about 20% increase of cellular growth in response to epidermal growth factor stiumlation, enhanced cellular sensitivity to gefitinib, decrease of epidermal growth factor-mediated phosphorylation of mitogen-activated protein kinase Homo sapiens
additional information 293/EGFR/shFUT8, stable knockdown mutant of intrinsic FUT8, about 20% decrease of cellular growth in response to epidermal growth factor stimulation Homo sapiens
additional information A549/FUT8, overexpression of FUT8 Homo sapiens
additional information A549/shFUT8, knockdown mutant of intrinsic FUT8, no enzyme activity, decrease of cellular growth in response to epidermal growth factor stimulation, decreased sensitivity of A549 cells to gefitinib Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
gefitinib
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Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
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Homo sapiens
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HEK-293 cell
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Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
44.1 U/l in HEK-293 cells transfected with epidermal growth factor receptor and FUT8, 1.8 U/l in HEK-293 cells transfected only with epidermal growth factor receptor Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine-bi-(4-(2-pyridylamino)butylamine pH 7.0, 37°C, 6 h, reaction stopped by heating at 100°C for 1 min Homo sapiens GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine-bi-(4-(2-pyridylamino)butylamine)
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Synonyms

Synonyms Comment Organism
alpha1,6-fucosyltransferase
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Homo sapiens
FUT8
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Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Homo sapiens