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Literature summary for 2.4.1.66 extracted from

  • Watt, S.A.; Dayal, J.H.; Wright, S.; Riddle, M.; Pourreyron, C.; McMillan, J.R.; Kimble, R.M.; Prisco, M.; Gartner, U.; Warbrick, E.; McLean, W.H.; Leigh, I.M.; McGrath, J.A.; Salas-Alanis, J.C.; Tolar, J.; South, A.P.
    Lysyl hydroxylase 3 localizes to epidermal basement membrane and is reduced in patients with recessive dystrophic epidermolysis bullosa (2015), PLoS ONE, 10, e0137639.
    View publication on PubMedView publication on EuropePMC
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
 2 * 80000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucose + (2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine-[procollagen] Homo sapiens
-
 UDP + (2S,5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine-[procollagen]
-
 ?
UDP-glucose + type VII collagen Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte
-
 Homo sapiens
-
skin epidermal basement membrane Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + (2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine-[procollagen]
-
 Homo sapiens UDP + (2S,5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine-[procollagen]
-
 ?
UDP-glucose + type VII collagen
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? 2 * 80000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
LH3
-
 Homo sapiens
lysyl hydroxylase 3
-
 Homo sapiens
PLOD3
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme levels are reduced in patients with recessive dystrophic epidermolysis bullosa down
Homo sapiens exogenous type VII collagen do not alter enzyme expression in cultured recessive dystrophic epidermolysis bullosa keratinocytes additional information