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Literature summary for 2.4.1.66 extracted from

  • Han, X.; Karpakka, J.; Kainulainen, H.; Takala, T.E.S.
    Effects of streptozotocin-induced diabetes, physical training and their combination on collagen biosynthesis in rat skeletal muscle (1995), Acta Physiol. Scand., 155, 9-16.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information training increases GGT activity in gastrocnemius in non-diabetic rats, in combination with diabetes the activity remains constant Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information total GGT activity decreases in vastus lateralis, rectus femoris and gastrocnemius muscles in streptozotocin-induced diabetic rats Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen Rattus norvegicus posttranslational modification of collagen UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
 ?
UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen Rattus norvegicus marker enzyme of collagen biosynthesis UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Sprague-Dawley rats, 10 weeks old
-

Source Tissue

Source Tissue Comment Organism Textmining
gastrocnemius
-
 Rattus norvegicus
-
rectus femoris
-
 Rattus norvegicus
-
vastus lateralis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen heat-denatured gelatinized calf skin collagen Rattus norvegicus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen product is glucosylgalactosylhydroxylysine-collagen ?
UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen posttranslational modification of collagen Rattus norvegicus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
 ?
UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen marker enzyme of collagen biosynthesis Rattus norvegicus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
 ?