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Literature summary for 2.4.1.65 extracted from

  • Guo, Q.; Guo, B.; Wang, Y.; Wu, J.; Jiang, W.; Zhao, S.; Qiao, S.; Wu, Y.
    Functional analysis of alpha1,3/4-fucosyltransferase VI in human hepatocellular carcinoma cells (2012), Biochem. Biophys. Res. Commun., 417, 311-317.
    View publication on PubMed
Search for more literature for 2.4.1.65

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocellular carcinoma cell
-
 Homo sapiens
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SK-HEP-1 cell
-
 Homo sapiens
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SMMC-7721 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
alpha1,3/4-fucosyltransferase VI
-
 Homo sapiens
FUT6
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is upregulated 3fold in hepatocellular carcinoma cells up

General Information

General Information Comment Organism
physiological function the enzyme plays an important role in hepatocellular carcinoma growth by regulating the PI3K/Akt signaling pathway. Elevating enzyme expression markedly induces intracellular Akt phosphorylation, and suppresses the expression of the cyclin-dependent kinases inhibitor p21. Enzyme overexpression of enhances S-phase cell population, promotes cell growth and colony formation ability Homo sapiens