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Literature summary for 2.4.1.65 extracted from

  • Barthel, S.; Wiese, G.; Cho, J.; Opperman, M.; Hays, D.; Siddiqui, J.; Pienta, K.; Furie, B.; Dimitroff, C.
    Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking (2009), Proc. Natl. Acad. Sci. USA, 106, 19491-19496.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell FT3, FT6, and FT7 Homo sapiens
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prostate FT4 and FT9 Homo sapiens
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Synonyms

Synonyms Comment Organism
alpha-1,3 fucosyltransferase
-
 Homo sapiens
FT3
-
 Homo sapiens
FT6
-
 Homo sapiens
FT7
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens FT4 expression is 3- to 15fold lower in metastatic specimens down
Homo sapiens FT3, FT6, and FT7 are markedly elevated in bone- and liver-metastatic prostate cancer and dictate synthesis of sialyl Lewis X and endothelial selectin ligands on metastatic prostate cancer cells up

General Information

General Information Comment Organism
physiological function alpha-1,3 fucosyltransferases can enhance metastatic efficiency of prostate cancer by triggering an endothelial selectin-dependent trafficking mechanism. Upregulated FT3, FT6, or FT7 expression induces robust prostate cancer PC-3 cell adhesion to bone marrow endothelium and to inflamed postcapillary venules in an endothelial selectin-dependent manner. FT3, FT6, and FT7 induce sialyl Lewis X expression on metastatic prostate cancer PC-3 cells. Elevated FT7 expression promotes PC-3 cell trafficking to and retention in bone marrow through an endothelial selectin dependent event Homo sapiens