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Literature summary for 2.4.1.65 extracted from
- Structure/function study of Lewis alpha3- and alpha3/4-fucosyltransferases: the alpha1,4 fucosylation requires an aromatic residue in the acceptor-binding domain (2004), Glycobiology, 14, 347-356.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Gorilla gorilla |
- |
Pongo pygmaeus |
- |
Hylobates lar |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R110H | less than 10% of the wild type alpha-1,3-activity and undetectable alpha-1,4-activity | Homo sapiens |
| R110K | less than 10% of the wild type alpha-1,3-activity and undetectable alpha-1,4-activity | Homo sapiens |
| R110N | less than 10% of the wild type alpha-1,3-activity and undetectable alpha-1,4-activity | Homo sapiens |
| R110Q | less than 10% of the wild type alpha-1,3-activity and undetectable alpha-1,4-activity | Homo sapiens |
| R110W | no alpha-1,3-activity or alpha-1,4-activity | Homo sapiens |
| W111A | alpha-1,4-activity is decreased to 10-20% of the wild type activity | Homo sapiens |
| W111F | alpha-1,4-activity is decreased to 42% of the wild type activity | Homo sapiens |
| W111Y | alpha-1,4-activity is decreased to 58% of the wild type activity | Homo sapiens |
| W124A | alpha-1,4-activity is decreased to 20% of the wild type activity | Homo sapiens |
| W124F | alpha-1,4-activity is decreased to 17% of the wild type activity | Homo sapiens |
| W124R | undetectable alpha-1,4-activity | Homo sapiens |
| W124V | undetectable alpha-1,4-activity | Homo sapiens |
| W124Y | alpha-1,4-activity is decreased to 52% of the wild type activity | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
GDP-fucose | mutant W124R, with Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin | Homo sapiens |  |
| 0.034 | - |
GDP-fucose | mutant W111Y, with Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin | Homo sapiens | |
| 0.035 | - |
GDP-fucose | mutant W124Y, with Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin | Homo sapiens | |
| 0.035 | - |
GDP-fucose | wildtype, with Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin | Homo sapiens | |
| 0.037 | - |
GDP-fucose | mutant W111F, with Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin | Homo sapiens | |
| 0.038 | - |
GDP-fucose | wildtype, with Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin | Homo sapiens | |
| 0.046 | - |
GDP-fucose | mutant W111A, with Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin | Homo sapiens | |
| 0.1 | - |
Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin | mutant W124R | Homo sapiens | |
| 0.2 | - |
Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin | wildtype | Homo sapiens | |
| 0.3 | - |
Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin | mutant W111F | Homo sapiens | |
| 0.3 | - |
Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin | mutant W111Y | Homo sapiens | |
| 1.1 | - |
Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin | wildtype | Homo sapiens | |
| 1.3 | - |
Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin | mutant W124Y | Homo sapiens | |
| 2.5 | - |
Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin | mutant W111A | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 41800 | - |
SDS-PAGE, immunoblot | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gorilla gorilla | Q8HYJ6 | - |
- |
| Gorilla gorilla | Q8HYJ7 | - |
- |
| Homo sapiens | P21217 | - |
- |
| Homo sapiens | P51993 | - |
- |
| Homo sapiens | Q11128 | - |
- |
| Hylobates lar | Q8HYJ3 | - |
- |
| Pongo pygmaeus | Q8HYJ4 | - |
- |
| Pongo pygmaeus | Q8HYJ5 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GDP-fucose + Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin | type 1 reaction | Homo sapiens | GDP + Fuc-alpha-1,2Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc-sp-biotin | - |
? | |
| GDP-fucose + Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin | type 1 reaction | Pongo pygmaeus | GDP + Fuc-alpha-1,2Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc-sp-biotin | - |
? | |
| GDP-fucose + Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin | type 1 reaction | Hylobates lar | GDP + Fuc-alpha-1,2Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc-sp-biotin | - |
? | |
| GDP-fucose + Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin | type 1 reaction | Gorilla gorilla | GDP + Fuc-alpha-1,2Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc-sp-biotin | - |
? | |
| GDP-fucose + Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin | type 2 reaction | Homo sapiens | GDP + Fuc-alpha-1,2Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc-sp-biotin | - |
? | |
| GDP-fucose + Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin | type 2 reaction | Gorilla gorilla | GDP + Fuc-alpha-1,2Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc-sp-biotin | - |
? | |
| GDP-fucose + Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin | type 2 reaction | Pongo pygmaeus | GDP + Fuc-alpha-1,2Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc-sp-biotin | - |
? | |
| GDP-fucose + Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin | type 2 reaction | Hylobates lar | GDP + Fuc-alpha-1,2Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc-sp-biotin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha-3-FUT | - |
Homo sapiens |
| alpha-3-FUT | - |
Gorilla gorilla |
| alpha-3/4-FUT | - |
Homo sapiens |
| alpha-3/4-FUT | - |
Pongo pygmaeus |
| alpha-3/4-FUT | - |
Hylobates lar |
| alpha-3/4-FUT | - |
Gorilla gorilla |
| fucosyltransferase 3 | - |
Homo sapiens |
| fucosyltransferase 3 | - |
Pongo pygmaeus |
| fucosyltransferase 5 | - |
Homo sapiens |
| fucosyltransferase 5 | - |
Pongo pygmaeus |
| fucosyltransferase 5 | - |
Hylobates lar |
| fucosyltransferase 5 | - |
Gorilla gorilla |
| fucosyltransferase 6 | - |
Homo sapiens |
| fucosyltransferase 6 | - |
Gorilla gorilla |
| FucT-III | - |
Homo sapiens |
| FucT-III | - |
Pongo pygmaeus |
| FucT-V | - |
Homo sapiens |
| FucT-V | - |
Pongo pygmaeus |
| FucT-V | - |
Hylobates lar |
| FucT-V | - |
Gorilla gorilla |
| FucT-VI | - |
Homo sapiens |
| FucT-VI | - |
Gorilla gorilla |
| FUT3 | - |
Homo sapiens |
| FUT3 | - |
Pongo pygmaeus |
| FUT5 | - |
Homo sapiens |
| FUT5 | - |
Pongo pygmaeus |
| FUT5 | - |
Hylobates lar |
| FUT5 | - |
Gorilla gorilla |
| FUT6 | - |
Homo sapiens |
| FUT6 | - |
Gorilla gorilla |
| Lewis alpha-3-fucosyltransferase | - |
Homo sapiens |
| Lewis alpha-3-fucosyltransferase | - |
Gorilla gorilla |
| Lewis alpha-3/4-fucosyltransferase | - |
Homo sapiens |
| Lewis alpha-3/4-fucosyltransferase | - |
Pongo pygmaeus |
| Lewis alpha-3/4-fucosyltransferase | - |
Hylobates lar |
| Lewis alpha-3/4-fucosyltransferase | - |
Gorilla gorilla |
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