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Literature summary for 2.4.1.56 extracted from

  • Kahler, C.M.; Carlson, R.W.; Rahman, M.M.; Martin, L.E.; Stephens, D.S.
    Two glycosyltransferase genes, lgtF and rfaK, constitute the lipooligosaccharide ice (inner core extension) biosynthesis operon of Neisseria meningitidis (1996), J. Bacteriol., 178, 6677-6684.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.56

Cloned(Commentary)

Cloned (Comment) Organism
rfaK gene encodes the alpha-1,2-N-acetylglucosamine transferase, 1065-bp open reading frame, rfaK gene is cotranscribed with lgtF as polycistronic message from a promoter upstream of lgtF: ice operon, lgtA gene encodes beta-1,3-N-acetylglucosamine transferase Neisseria meningitidis

Protein Variants

Protein Variants Comment Organism
additional information Tn916 mutagenesis: insertion mutant with inactivated enzyme prevents addition of GlcNAc and alpha-chain lacto-N-neotetraose to the lipooligosaccharide inner core Neisseria meningitidis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Neisseria meningitidis inner-core biosynthesis of lipooligosaccharide, an outer membrane glycolipid ?
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 ?
additional information Neisseria meningitidis H44/76 inner-core biosynthesis of lipooligosaccharide, an outer membrane glycolipid ?
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 ?

Organism

Organism UniProt Comment Textmining
Neisseria meningitidis
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 strains M981, NMB
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Neisseria meningitidis
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 obligate human pathogen
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Neisseria meningitidis
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 immunotype L3
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Neisseria meningitidis H44/76
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 immunotype L3
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information different genes lgtA and rfaK encode enzymes which transfer N-acetylglucosamine to lipooligosaccharides, lgtA: beta-1,3-N-acetylglucosamine transferase, rfaK: alpha-1,2-N-acetylglucosamine transferase Neisseria meningitidis ?
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 ?
additional information inner-core biosynthesis of lipooligosaccharide, an outer membrane glycolipid Neisseria meningitidis ?
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 ?
additional information different genes lgtA and rfaK encode enzymes which transfer N-acetylglucosamine to lipooligosaccharides, lgtA: beta-1,3-N-acetylglucosamine transferase, rfaK: alpha-1,2-N-acetylglucosamine transferase Neisseria meningitidis H44/76 ?
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 ?
additional information inner-core biosynthesis of lipooligosaccharide, an outer membrane glycolipid Neisseria meningitidis H44/76 ?
-
 ?
UDP-N-acetyl-D-glucosamine + lipooligosacccharide transfers N-acetylglucosamine to lipooligosaccharides, structure of the lipooligosaccharide Neisseria meningitidis UDP + N-acetyl-D-glucosaminyllipooligosaccharide
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 ?
UDP-N-acetyl-D-glucosamine + lipooligosacccharide transfers N-acetylglucosamine to lipooligosaccharides, structure of the lipooligosaccharide Neisseria meningitidis H44/76 UDP + N-acetyl-D-glucosaminyllipooligosaccharide
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 ?