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Literature summary for 2.4.1.47 extracted from

  • Fewou, S.N.; Bussow, H.; Schaeren-Wiemers, N.; Vanier, M.T.; Macklin, W.B.; Gieselmann, V.; Eckhardt, M.
    Reversal of non-hydroxy:alpha-hydroxy galactosylceramide ratio and unstable myelin in transgenic mice overexpressing UDP-galactose:ceramide galactosyltransferase (2005), J. Neurochem., 94, 469-481.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information overexpression of enzyme results in 4fold increase in activity and concomitant decrease in alpha-hydroxylated galactosylceramide and significant up-regulation of the myelin and lymphocyte protein. Animals developed a progressive hindlimb paralysis and demyelination in the central nervous system Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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overexpression in transgenic Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
oligodendrocyte overexpression of enzyme results in 4fold increase in activity and concomitant decrease in alpha-hydroxylated galactosylceramide and significant up-regulation of the myelin and lymphocyte protein Rattus norvegicus
-