Literature summary for 2.4.1.41 extracted from

Fritz, T.A.; Hurley, J.H.; Trinh, L.B.; Shiloach, J.; Tabak, L.A.
The beginnings of mucin biosynthesis: the crystal structure of UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1 (2004), Proc. Natl. Acad. Sci. USA, 101, 15307-15312.

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Cloned(Commentary)

Cloned (Comment)	Organism
ppGaNTase-T1 (mppGaNTase-T1) is expressed as a fusion protein with maltose-binding protein at the N terminus and residues 42559 of mppGaNTase-T1 at the C terminus separated by a tobacco etch virus protease recognition sequence. The fusion protein is expressed in Pichia pastoris	Mus musculus

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystals of mppGaNTase-T1 (without maltose-binding protein) are grown by hanging drop vapor diffusion at room temperature	Mus musculus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	ion complexed by invariant D209 and H211 of the DXH motif and by invariant H344	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-N-acetyl-D-galactosamine + polypeptide	Mus musculus	initiates the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine from UDP-GalNAc to Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-alpha-1-O-Ser/Thr)	UDP + N-acetyl-D-galactosaminyl-polypeptide	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O08912	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Mus musculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-N-acetyl-D-galactosamine + polypeptide	initiates the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine from UDP-GalNAc to Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-alpha-1-O-Ser/Thr)	Mus musculus	UDP + N-acetyl-D-galactosaminyl-polypeptide	-	?

Synonyms

Synonyms	Comment	Organism
pp-GaNTase	-	Mus musculus
ppGaNTase-T1	-	Mus musculus
UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1	-	Mus musculus

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Release 2023.1 (January 2023)