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Literature summary for 2.4.1.41 extracted from

  • Bennett, E.P.; Hassan, H.; Hollingsworth, M.A.; Clausen, H.
    A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates (1999), FEBS Lett., 460, 226-230.
    View publication on PubMed
Search for more literature for 2.4.1.41

Activating Compound

Activating Compound Comment Organism Structure
additional information GalNAc-T7: selectively activated by partial GalNAc glycosylation of peptide substrates derived from the tandem repeats of human Muc2 and rat submaxillary gland mucin Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
GalNAc-T7 is cloned and expressed in insect Sf9 cells, open reading frame of 1974 bp, GALNT7 gene encoding GalNAc-T7 is localized on chromosome 4q31.1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane GalNAc-T7: type II transmembrane protein with a hydrophobic signal anchor sequence in residues 10-24 Homo sapiens 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + polypeptide Homo sapiens GalNAc-T7: functions as a follow-up enzyme in the initiation step of O-glycosylation UDP + N-acetyl-D-galactosaminyl-polypeptide
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 ?
UDP-N-acetyl-D-galactosamine + polypeptide Homo sapiens initiation of mucin-type O-glycosylation by a family of polypeptide GalNAc-transferases, of which each has a unique function UDP + N-acetyl-D-galactosaminyl-polypeptide
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86SF2 GalNAc-T7
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information GalNAc-T7: no activity with non-glycosylated peptides and GalNAc-glycosylated Muc1 substrate Homo sapiens ?
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 ?
additional information multiple enzyme isoforms Homo sapiens ?
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 ?
additional information amino acid sequences of seven GalNAc-transferases Homo sapiens ?
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 ?
UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide GalNAc-T7: exclusive specificity for partially GalNAc-glycosylated acceptor substrates, GalNAc-glycosylated peptide substrates derived from the tandem repeats of human Muc2 and rat submandibular gland mucin, specificity of GalNAc-T4 Homo sapiens UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide
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 ?
UDP-N-acetyl-D-galactosamine + polypeptide
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 Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
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 ?
UDP-N-acetyl-D-galactosamine + polypeptide GalNAc-T7: functions as a follow-up enzyme in the initiation step of O-glycosylation Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
UDP-N-acetyl-D-galactosamine + polypeptide initiation of mucin-type O-glycosylation by a family of polypeptide GalNAc-transferases, of which each has a unique function Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?