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Literature summary for 2.4.1.38 extracted from

  • Brown, J.R.; Yang, F.; Sinha, A.; Ramakrishnan, B.; Tor, Y.; Qasba, P.K.; Esko, J.D.
    Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis (2009), J. Biol. Chem., 284, 4952-4959.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.38

Crystallization (Commentary)

Crystallization (Comment) Organism
mutant enzyme M340H/C338T in complex with Glc-NAcbeta1-3Galbeta-O-naphthalenemethanol, hanging drop vapor diffusion method, using MES-NaOH buffer (pH 6.0), 1.5 M ammonium sulfate, and 3% dioxane Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-naphthylmethyl 2-acetamido-3,6-di-O-acetyl-2,4-dideoxy-4-fluoro-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-D-galactopyranoside
-
 Homo sapiens
2-naphthylmethyl 2-acetamido-3,6-di-O-acetyl-2,4-dideoxy-4-methoxy-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-D-galactopyranoside
-
 Homo sapiens
2-naphthylmethyl 2-acetamido-3,6-di-O-acetyl-2,4-dideoxy-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-D-galactopyranoside
-
 Homo sapiens
2-naphthylmethyl 2-acetamido-3,6-di-O-acetyl-4-amino-2,4-dideoxy-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-Dgalactopyranoside
-
 Homo sapiens
2-naphthylmethyl 2-acetamido-3,6-di-O-acetyl-4-azido-2,4-dideoxy-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-Dgalactopyranoside
-
 Homo sapiens
2-naphthylmethyl 2-acetamido-4,6-di-O-acetyl-2,3-dideoxy-3-fluoro-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-D-galactopyranoside
-
 Homo sapiens
2-naphthylmethyl 2-acetamido-4,6-di-O-acetyl-2,3-dideoxy-3-methoxy-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-D-galactopyranoside
-
 Homo sapiens
2-naphthylmethyl 2-acetamido-4,6-di-O-acetyl-2,3-dideoxy-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-Dgalactopyranoside
-
 Homo sapiens
Glc-NAcbeta1-3Galbeta-O-naphthalenemethanol
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
 Glc-NAcbeta1-3Galbeta-O-naphthalenemethanol
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P15291
-
-

Source Tissue

Source Tissue Comment Organism Textmining
U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-galactose + Glc-NAcbeta1-3Galbeta-O-naphthalenemethanol
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
beta1-4-galactosyltransferase
-
 Homo sapiens
beta1-4GalT1
-
 Homo sapiens