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Literature summary for 2.4.1.38 extracted from
- Down-regulation of beta 1,4GalT V at protein level contributes to arsenic trioxide-induced glioma cell apoptosis (2008), Cancer Lett., 267, 96-105.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | beta 1,4GalT V inhibitors enhance the therapeutic effect of As2O3 for malignant glioma | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | beta 1,4GalT V antisense constructs interfere with beta 1,4GalT V leading to promotion of As2O3-induced glioma cell apoptosis, while overexpression of beta 1,4GalT V inhibits it, overview | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | As2O3 significantly decreases beta 1,4GalT V expression level in in glioma cells, which increases the glioma cell apoptosis induced by As2O3, overviewoverview | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | beta 1,4GalT V galactosylates the beta1,6-GlcNAc branch of N-glycans at the cell surface and of secreted glycoproteins, and functions as a positive regulator in glioma development, overview. As2O3-induced gioma cell apoptosis mechanism involves beta 1,4GalT V inhibition, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Renatured (Commentary)
| Renatured (Comment) | Organism |
|---|---|
| expression of HA-tagged beta 1,4GalT V | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| glioma cell | - |
Homo sapiens | - |
| SHG-44 cell | - |
Homo sapiens | - |
| U-251 cell | - |
Homo sapiens | - |
| U-87MG cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | beta 1,4GalT V galactosylates the beta1,6-GlcNAc branch of N-glycans at the cell surface and of secreted glycoproteins, and functions as a positive regulator in glioma development, overview. As2O3-induced gioma cell apoptosis mechanism involves beta 1,4GalT V inhibition, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta 1,4GalT V | - |
Homo sapiens |
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