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Literature summary for 2.4.1.38 extracted from

  • Li, Z.; Zong, H.; Kong, X.; Zhang, S.; Wang, H.; Sun, Q.; Gu, J.
    Cell surface beta 1, 4-galactosyltransferase 1 promotes apoptosis by inhibiting epidermal growth factor receptor pathway (2006), Mol. Cell. Biochem., 291, 69-76.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in human hepatocarcinoma SMMC-7721 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information autophosphorylation of epidermal growth factor receptor, EGFR, and phosphorylation of protein kinase B, PKB/Akt, and extracellular signalregulated protein kinase1/2,ERK1/2, which are downstream molecules of EGFR, are reduced in cell surface beta1,4GT1-overexpressing SMMC-7721 cells, phenotype, overview, knockdown of beta1,4GT1 by siRNA increases the autophosphorylation of EGFR at Tyr1068 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-
Golgi apparatus
-
Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the cell surface enzyme promotes apoptosis by inhibiting the epidermal growth factor receptor pathway via inhibition of the autophosphorylation of epidermal growth factor receptor especially at Try 1068, mechanism, overview ?
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide Homo sapiens
-
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the cell surface enzyme promotes apoptosis by inhibiting the epidermal growth factor receptor pathway via inhibition of the autophosphorylation of epidermal growth factor receptor especially at Try 1068, mechanism, overview Homo sapiens ?
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
-
Homo sapiens UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
?

Synonyms

Synonyms Comment Organism
beta 1,4-galactosyltransferase 1
-
Homo sapiens
beta1,4GT1
-
Homo sapiens