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Literature summary for 2.4.1.38 extracted from

  • Brockhausen, I.; Benn, M.; Bhat, S.; Marone, S.; Riley, J.G.; Montoya-Peleaz, P.; Vlahakis, J.Z.; Paulsen, H.; Schutzbach, J.S.; Szarek, W.A.
    UDP-Gal: GlcNAc-R beta1,4-galactosyltransferase - a target enzyme for drug design. Acceptor specificity and inhibition of the enzyme (2006), Glycoconj. J., 23, 525-541.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme is a target enzyme for drug design Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
1,6-dithio-N-butyryl-GlcNbeta-(2-naphthyl) 45% inhibition at 1.0 mM Bos taurus
1-thio-N-butyryl-GlcNbeta-(2-naphthyl) uncompetitive, complete inhibition at 1.0 mM, 85% inhibition at 0.2 mM Bos taurus
1-thioGlcNAcbeta-(2-naphthyl) 91% inhibition at 1.0 mM Bos taurus
6-thio-N-butyryl-GlcNbeta-(2-naphthyl) 19% inhibition at 1.0 mM Bos taurus
GlcNAcbeta-(2-naphthyl) 92% inhibition at 1.0 mM Bos taurus
additional information inhibitor synthesis and potency, mechanism of inhibition, overview Bos taurus
N-butyryl-GlcNbeta-(2-naphthyl) 87% inhibition at 1.0 mM Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme catalyzes the transfer of Gal from UDP-Gal to GlcNAc-terminating acceptors with inversion of configuration of the glycosidic linkage, in presence of beta-lactalbumin, the enzyme changes its specificity to become lactose synthase, EC 2.4.1.22, and transfers Gal to glucose to synthesize lactose, substrate specificity, e.g. with GlcNAc-terminating O-glycopeptides, no activity with N-trimethylacetyl-GlcN, N,N-dimethyl-GlcN, N-isopropyl-GlcN, and N-(4-MeOBn)GlcN, overview Bos taurus ?
-
?
UDP-galactose + 3-deoxy-3-fluoro-GlcNAcbeta-Bn
-
Bos taurus UDP + Galbeta(1-4)3-deoxy-3-fluoro-GlcNAcbeta-Bn
-
?
UDP-galactose + 6-deoxy-GlcNAcbeta-Bn low activity Bos taurus UDP + Galbeta(1-4)6-deoxy-GlcNAcbeta-Bn
-
?
UDP-galactose + 6-thio-GlcNAcbeta-Bn low activity Bos taurus UDP + Galbeta(1-4)6-thio-GlcNAcbeta-Bn
-
?
UDP-galactose + GlcNAcbeta-Bn
-
Bos taurus UDP + Galbeta(1-4)GlcNAcbeta-Bn
-
?
UDP-galactose + N-4-toluenesulfonyl-GlcN
-
Bos taurus UDP + Galbeta(1-4)N-4-toluenesulfonyl-GlcN
-
?
UDP-galactose + N-acetylglucosamine
-
Bos taurus UDP + N-acetyllactosamine
-
?
UDP-galactose + N-butyryl-GlcNbeta-Bn
-
Bos taurus UDP + Galbeta(1-4)N-butyryl-GlcNbeta-Bn
-
?
UDP-galactose + N-methanesulfonyl-GlcN
-
Bos taurus UDP + Galbeta(1-4)N-methanesulfonyl-GlcN
-
?
UDP-galactose + N-trifluoroacetyl-GlcN
-
Bos taurus UDP + Galbeta(1-4)N-trifluoroacetyl-GlcN
-
?
UDP-galactose + T(GlcNAcbeta3GalNAcbeta)TTVTPTPTG
-
Bos taurus ?
-
?
UDP-galactose + T(GlcNAcbeta6GalNAcbeta)TTVTPTPTG
-
Bos taurus ?
-
?
UDP-galactose + T(GlcNAcbeta6[GlcNAcbeta3]GalNAcbeta)TTVTPTPTG
-
Bos taurus ?
-
?
UDP-galactose + TT(GlcNAcbeta3GalNAcbeta)TVTPTPTG
-
Bos taurus ?
-
?
UDP-galactose + TT(GlcNAcbeta6GalNAcbeta)TVTPTPTG
-
Bos taurus ?
-
?
UDP-galactose + TT(GlcNAcbeta6[GlcNAcbeta3]GalNAcbeta)TVTPTPTG
-
Bos taurus ?
-
?
UDP-galactose + TTTV (GlcNAcbeta3GalNAcbeta)TPTPTG
-
Bos taurus ?
-
?
UDP-galactose + TTTV(GlcNAcbeta6GalNAcbeta)TPTPTG
-
Bos taurus ?
-
?
UDP-galactose + TTTV(GlcNAcbeta6[GlcNAcbeta3]GalNAcbeta)TPTPTG
-
Bos taurus ?
-
?
UDP-galactose + TTTVTP(GlcNAcbeta3GalNAcbeta)TPTG
-
Bos taurus ?
-
?
UDP-galactose + TTTVTP(GlcNAcbeta6GalNAcbeta)TPTG
-
Bos taurus ?
-
?
UDP-galactose + TTTVTPTP(GlcNAcbeta3GalNAcbeta)TG
-
Bos taurus ?
-
?
UDP-galactose + TTTVTPTP(GlcNAcbeta6[GlcNAcbeta3]GalNAcbeta)TG
-
Bos taurus ?
-
?

Synonyms

Synonyms Comment Organism
beta1,4-Gal-transferase T1
-
Bos taurus
beta4GalT
-
Bos taurus
More cf. EC 2.4.1.90, the enzyme belongs to the CAZY family 7 of inverting glycosyltransferases Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics Bos taurus
0.01
-
1-thio-N-butyryl-GlcNbeta-(2-naphthyl) pH 7.0 Bos taurus