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Literature summary for 2.4.1.38 extracted from

  • Sato, T.; Furukawa, K.; Bakker, H.; Van den Eijnden, D.H.; Van Die, I.
    Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal: GlcNAc beta-1,4-galactosyltransferase (1998), Proc. Natl. Acad. Sci. USA, 95, 472-477.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
enzyme fused to protein A is expressed as a soluble form in COS-7 cells Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ 20 mM, stimulates Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O43286
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MRK-nu-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDPgalactose + GlcNAcbeta-S-p-NP
-
 Homo sapiens UDP + Galbeta1-4 GlcNAcbeta-S-p-NP
-
 ?
UDPgalactose + GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha1-3Manbeta1-O(CH2)8COOCH2-mNP
-
 Homo sapiens UDP + Galbeta1-4 GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha1-3Manbeta1-O(CH2)8COOCH2-mNP
-
 ?
UDPgalactose + glucose enzyme has no lactose synthase activity in presence of alpha-lactalbumin Homo sapiens lactose + UDP
-
 ?
UDPgalactose + N-acetylglucosamine 7% of the activity with GlcNAcbeta-S-pNP Homo sapiens UDP + N-acetyllactosamine
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Homo sapiens