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Literature summary for 2.4.1.37 extracted from

  • Gagnon, S.M.; Meloncelli, P.J.; Zheng, R.B.; Haji-Ghassemi, O.; Johal, A.R.; Borisova, S.N.; Lowary, T.L.; Evans, S.V.
    High resolution structures of the human ABO(H) blood group enzymes in complex with donor analogs reveal that the enzymes utilize multiple donor conformations to bind substrates in a stepwise manner (2015), J. Biol. Chem., 290, 27040-27052.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
using 1% (w/v) polyethylene glycol 4000, 4.5-5% (w/v) 2-methyl-2,4-pentanediol, 100 mM ammonium sulfate, 70 mM sodium chloride, 50 mM N-[2-acetamido]-2-iminodiacetic acid buffer, pH 7.5, 30 mM sodium acetate buffer, pH 4.6, and 5 mM MnCl2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-galactose + alpha-L-fucosyl-(1,2)-D-galactosyl-R Homo sapiens
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UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl(1,2)]-D-galactosyl-R
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P16442
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-galactose + alpha-L-fucosyl-(1,2)-D-galactosyl-R
-
Homo sapiens UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl(1,2)]-D-galactosyl-R
-
?

Synonyms

Synonyms Comment Organism
alpha-(1->3)-galactosyltransferase
-
Homo sapiens
GTB
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme catalyzes the final step in ABO(H) blood group B antigen synthesis through sugar transfer from activated donor to the H antigen acceptor Homo sapiens