Literature summary for 2.4.1.34 extracted from

Kondoh, O.; Inagaki, Y.; Fukuda, H.; Mizuguchi, E.; Ohya, Y.; Arisawa, M.; Shimma, N.; Aoki, Y.; Sakaitani, M.; Watanabe, T.
Piperazine propanol derivative as a novel antifungal targeting 1,3-beta-D-glucan synthase (2005), Biol. Pharm. Bull., 28, 2138-2141.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2,6-difluoro-phenyl)-carbamic acid 3-(4-benzothiazol-2-yl-piperazine-1-yl)-propyl ester	The piperazine propanol derivative GS1578 was identified as a potent inhibitor against 1,3-beta-D-glucan synthase, IC50: 0.16 microM.	Candida albicans

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	-	-
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	1,3-beta-D-glucan synthase catalyses the synthesis of 1,3-beta-D-glucan, the most abundant component of the fungal cell wall.	Candida albicans	?	-	?

Subunits

Subunits	Comment	Organism
More	1,3-beta-D-glucan synthase is composed of a putative catalytic subunit with sixteen putative transmembrane domains and a regulatory subunit encoded by CaFKS1/GSC1and CaRHO1 respectively.	Candida albicans
More	1,3-beta-D-glucan synthase is composed of a putative catalytic subunit with sixteen putative transmembrane domains encoded by a pair of closely related genes, FKS1/GSC1/CWH53/ETG1/CND1/PBR1/YLR342W and FKS2/GSC2/G4074/YGRO32W and a regulatory subunit encoded by RHO1.	Saccharomyces cerevisiae

Synonyms

Synonyms	Comment	Organism
1,3-beta-D-glucan 3-beta-D-glucosyltransferase	-	Saccharomyces cerevisiae
1,3-beta-D-glucan 3-beta-D-glucosyltransferase	-	Candida albicans
1,3-beta-D-glucan synthase	-	Saccharomyces cerevisiae
1,3-beta-D-glucan synthase	-	Candida albicans

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00016	-	The piperazine propanol derivative GS1578 was identified as a potent inhibitor against 1,3-beta-D-glucan synthase, IC50: 0.16 microM.	Candida albicans	(2,6-difluoro-phenyl)-carbamic acid 3-(4-benzothiazol-2-yl-piperazine-1-yl)-propyl ester

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Release 2023.1 (January 2023)