Literature summary for 2.4.1.34 extracted from

Wood, R.L.; Miller, T.K.; Wright, A.; McCarthy, P.; Taft, C.S.; Pomponi, S.; Selitrennikoff, C.P.
Characterization and optimization of in vitro assay conditions for (1,3)beta-glucan synthase activity from Aspergillus fumigatus and Candida albicans for enzyme inhibition screening (1998), J. Antibiot., 51, 665-675.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cilofungin	-	Aspergillus fumigatus
cilofungin	-	Candida albicans
cilofungin	-	Neurospora crassa
MK 991	-	Aspergillus fumigatus
MK 991	-	Candida albicans

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
protoplast	-	Candida albicans	-	-

Organism

Organism	UniProt	Comment	Textmining
Aspergillus fumigatus	-	-	-
Candida albicans	-	-	-
Neurospora crassa	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Candida albicans
-	Aspergillus fumigatus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.00126	-	-	Candida albicans
0.0048	-	-	Aspergillus fumigatus

Storage Stability

Storage Stability	Organism
-70°C, more than 25 weeks 100% activity	Candida albicans
-70°C, more than 26 weeks 100% activity	Aspergillus fumigatus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDPglucose + (1,3-beta-D-glucosyl)n	-	Neurospora crassa	UDP + (1,3-beta-D-glucosyl)n+1	-	?
UDPglucose + (1,3-beta-D-glucosyl)n	-	Candida albicans	UDP + (1,3-beta-D-glucosyl)n+1	-	?
UDPglucose + (1,3-beta-D-glucosyl)n	-	Aspergillus fumigatus	UDP + (1,3-beta-D-glucosyl)n+1	-	?

Temperature Stability [°C]

Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
4	-	half life: 2.8 h	Candida albicans
4	-	half life: 5 d	Aspergillus fumigatus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	-	Candida albicans
8	-	-	Aspergillus fumigatus

pH Range

pH Minimum	pH Maximum	Comment	Organism
6.4	8.8	-	Aspergillus fumigatus

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Release 2023.1 (January 2023)