Cloned (Comment) | Organism |
---|---|
expression in Streptomyces lividans | Streptomyces olivaceus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C | Streptomyces olivaceus | the enzyme is involved in biosynthesis of the antitumor polyketide elloramycin | dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C | - |
? | |
dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C | Streptomyces olivaceus Tü2353 | the enzyme is involved in biosynthesis of the antitumor polyketide elloramycin | dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces olivaceus | Q9F2F9 | - |
- |
Streptomyces olivaceus Tü2353 | Q9F2F9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C | the enzyme is involved in biosynthesis of the antitumor polyketide elloramycin | Streptomyces olivaceus | dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C | - |
? | |
dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C | dTDP-beta-L-rhamnose i.e. dTDP-6-deoxy-beta-L-mannose | Streptomyces olivaceus | dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C | - |
? | |
dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C | the enzyme is involved in biosynthesis of the antitumor polyketide elloramycin | Streptomyces olivaceus Tü2353 | dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C | - |
? | |
dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C | dTDP-beta-L-rhamnose i.e. dTDP-6-deoxy-beta-L-mannose | Streptomyces olivaceus Tü2353 | dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C | - |
? | |
additional information | when the elloramycin gene cluster is transformed into the mithramycin producer, Streptomyces argillaceus, four compounds are produced by the recombinant strain: the elloramycin aglycon 8-demethyl-tetracenomycin C and three glycosylated derivatives. Two of them contained a D-olivose or a D-mycarose moiety attached to the aglycon, 8-demethyl-8-beta-D-olivosyl-tetracenomycin C and 8-demethyl-8-beta-D-mycarosyl-tetracenomycin C. The third one contains a diolivosyl disaccharide attached to the aglycon, 8-demethyl-8-beta-D-diolivosyl-3'-1''-D-L-tetracenomycin C. The enzyme transfesr individually D-olivose and D-mycarose or a diolivosyl disaccharide to the aglycon 8-demethyl-tetracenomycin C | Streptomyces olivaceus | ? | - |
? | |
additional information | when the elloramycin gene cluster is transformed into the mithramycin producer, Streptomyces argillaceus, four compounds are produced by the recombinant strain: the elloramycin aglycon 8-demethyl-tetracenomycin C and three glycosylated derivatives. Two of them contained a D-olivose or a D-mycarose moiety attached to the aglycon, 8-demethyl-8-beta-D-olivosyl-tetracenomycin C and 8-demethyl-8-beta-D-mycarosyl-tetracenomycin C. The third one contains a diolivosyl disaccharide attached to the aglycon, 8-demethyl-8-beta-D-diolivosyl-3'-1''-D-L-tetracenomycin C. The enzyme transfesr individually D-olivose and D-mycarose or a diolivosyl disaccharide to the aglycon 8-demethyl-tetracenomycin C | Streptomyces olivaceus Tü2353 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ElmGT | - |
Streptomyces olivaceus |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is involved in biosynthesis of the antitumor polyketide elloramycin | Streptomyces olivaceus |