Literature summary for 2.4.1.27 extracted from

Morera, S.; Lariviere, L.; Kurzeck, J.; Aschke-Sonnenborn, U.; Freemont, P.S.; Janin, J.; Ruger, W.
High resolution crystal structures of T4 phage beta-glucosyltransferase: Induced fit and effect of substrate and metal binding (2001), J. Mol. Biol., 311, 569-577.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
ternary complex between the T4 phage beta-glucosyltransferase, uridine diphosphoglucose and a DNA fragment containing an abasic site	Tequatrovirus T4

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	four of the six X-ray structures of the enzyme contain metal ions which activate the enzyme, including Mg2+ in forms 1 and 2 and Mn2+ or Ca2+. Mg2+, Mn2+ and Ca2+ bind near the beta-phosphate of the nucleotide, but they occupy slightly different positions	Tequatrovirus T4
Mg2+	four of the six X-ray structures of the enzyme contain metal ions which activate the enzyme, including Mg2+ in forms 1 and 2 and Mn2+ or Ca2+. Mg2+, Mn2+ and Ca2+ bind near the beta-phosphate of the nucleotide, but they occupy slightly different positions	Tequatrovirus T4
Mn2+	four of the six X-ray structures of the enzyme contain metal ions which activate the enzyme, including Mg2+ in forms 1 and 2 and Mn2+ or Ca2+. Mg2+, Mn2+ and Ca2+ bind near the beta-phosphate of the nucleotide, but they occupy slightly different positions	Tequatrovirus T4

Organism

Organism	UniProt	Comment	Textmining
Tequatrovirus T4	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-alpha-D-glucose + 5-hydroxymethylcytosine containing DNA	-	Tequatrovirus T4	UDP + beta-D-glucosyl-5-hydroxymethylcytosine containing DNA	-	?

Synonyms

Synonyms	Comment	Organism
T4 phage beta-glucosyltransferase	-	Tequatrovirus T4

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Release 2023.1 (January 2023)