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Literature summary for 2.4.1.260 extracted from

  • Izquierdo, L.; Mehlert, A.; Ferguson, M.A.
    The lipid-linked oligosaccharide donor specificities of Trypanosoma brucei oligosaccharyltransferases (2012), Glycobiology, 22, 696-703.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.260

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
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Trypanosoma brucei
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 gene ALG12
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Synonyms

Synonyms Comment Organism
ALG12
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 Trypanosoma brucei
alpha1-6-mannosyltransferase
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 Trypanosoma brucei
Dol-P-Man:Man7GlcNAc2-PP-Dol-alpha1-6-mannosyltransferase
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 Trypanosoma brucei
TbALG12
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 Trypanosoma brucei

General Information

General Information Comment Organism
malfunction the variant surface glycoprotein sVSG221 synthesized by the ALG12-/- parasites shows different glycosylation patterns to that synthesized by wild-type cells, changes in sVSG221 glycosylation induced by the deletion of the ALG12 gene, overview Trypanosoma brucei
physiological function oligosaccharyltransferase TbSTT3A is able to transfer Man7GlcNAc2 as well as Man5GlcNAc2 to its preferred acidic glycosylation site at residue Asn263 of variant surface protein. In a mutant lacking enzymic activity, i.e. in the absence of Man9GlcNAc2-PP-Dol, oligosaccharyltransferase TbSTT3B transfers both Man7GlcNAc2 and Man5GlcNAc2 to the remaining site at Asn428 of variant surface protein, albeit with low efficiency Trypanosoma brucei
physiological function the TbALG12 gene encodes the alpha1-6-mannosyltransferase that converts Man7GlcNAc2-PP-Dol to Man8GlcNAc2-PP-Dol Trypanosoma brucei