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Literature summary for 2.4.1.255 extracted from

  • Ma, X.; Liu, P.; Yan, H.; Sun, H.; Liu, X.; Zhou, F.; Li, L.; Chen, Y.; Muthana, M.M.; Chen, X.; Wang, P.G.; Zhang, L.
    Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT) (2013), PLoS ONE, 8, e63452.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.255

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0085
-
 UDP-GlcNAc pH 7.4, 37°C Homo sapiens
0.1418
-
 UDP-6-deoxy-GlcNAc pH 7.4, 37°C Homo sapiens
0.2821
-
 UDP-GlcNPr pH 7.4, 37°C Homo sapiens
0.3695
-
 UDP-4-deoxy-GalNAc pH 7.4, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15294
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
KKKYPGGSTPVSSANMM + UDP-4-deoxy-GalNAc
-
 Homo sapiens ? + UDP
-
 ?
KKKYPGGSTPVSSANMM + UDP-4-deoxy-GlcNAc 22.2% yield Homo sapiens ? + UDP
-
 ?
KKKYPGGSTPVSSANMM + UDP-6-deoxy-GalNAc 37.7% yield Homo sapiens ? + UDP
-
 ?
KKKYPGGSTPVSSANMM + UDP-6-deoxy-GlcNAc 85% yield Homo sapiens ? + UDP
-
 ?
KKKYPGGSTPVSSANMM + UDP-GlcNAc peptide acceptor derived from casein kinase II Homo sapiens ? + UDP
-
 ?
KKKYPGGSTPVSSANMM + UDP-GlcNAz peptide acceptor derived from casein kinase II Homo sapiens ? + UDP
-
 ?
KKKYPGGSTPVSSANMM + UDP-GlcNPr the close vicinity between Met501 and the N-acyl group of GlcNPr, as well as the hydrophobic environment near Met501, are responsible for the selective binding of UDP-GlcNPr Homo sapiens ? + UDP
-
 ?
additional information the substitution of the N-acyl group, deoxy modification of C6/C4-OH or epimerization of C4-OH of the GlcNAc in UDP-GlcNAc decrease its affinity to isoform short OGT. The backbone carbonyl oxygen of Leu653 and the hydroxyl group of Thr560 in sOGT contribute to the recognition of the sugar moiety via hydrogen bonds Homo sapiens ?
-
 ?