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Literature summary for 2.4.1.255 extracted from

  • Zhang, Z.; Costa, F.C.; Tan, E.P.; Bushue, N.; DiTacchio, L.; Costello, C.E.; McComb, M.E.; Whelan, S.A.; Peterson, K.R.; Slawson, C.
    O-GlcNAc transferase and O-GlcNAcase interact with Mi2beta at the Agamma-globin promoter (2016), J. Biol. Chem., 291, 15628-15640.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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General Information

General Information Comment Organism
physiological function O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), interact with the Agamma-globin promoter at the -566 GATA repressor site. O-GlcNAcylation is a mechanism of gamma-globin gene regulation, mediated by modulating the assembly of the GATA-1/FOG-1/Mi2beta repressor complex at the -566 GATA motif within the promoter. Inhibition of OGA by thiamet-G leads to increased occupancy of OGT, OGA and Mi2beta at the Agamma-globin promoter and decreased gamma-globin transcription level. Both OGT and OGA can interact with Mi2beta, GATA-1 and FOG-1, and Mi2beta is OGlcNAcylated Homo sapiens