Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | isoform 2 | Homo sapiens | 5739 | - |
nucleoplasm | isoforms 3 and 4 | Homo sapiens | 5654 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15294 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | endogenous mitochondrial isoform 2 of OGT is not detected in a range of human cell lines, experiments suggest the expression of only a single OGT isoform. Overexpression of the nucleocytoplasmic OGT isoform leads to increased O-GlcNAcylation of mitochondrial proteins, nucleocytoplasmic OGT is necessary and sufficient for the generation of the O-GlcNAc mitochondrial proteome | Homo sapiens |