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Literature summary for 2.4.1.255 extracted from

  • Caldwell, S.A.; Jackson, S.R.; Shahriari, K.S.; Lynch, T.P.; Sethi, G.; Walker, S.; Vosseller, K.; Reginato, M.J.
    Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1 (2010), Oncogene, 29, 2831-2842.
    View publication on PubMed
Search for more literature for 2.4.1.255

Application

Application Comment Organism
medicine pharmacological inhibition of OGT in breast cancer cells has similar anti-growth and anti-invasion effects. OGT may represent novel therapeutic targets for breast cancer Homo sapiens

Protein Variants

Protein Variants Comment Organism
DELTAN-DELTAKEN-FoxM1 O-GlcNAcation required the N terminus Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BT-20 cell
-
 Homo sapiens
-
MCF-10A cell mammary epithelial cell Homo sapiens
-
MCF-12A cell mammary epithelial cell Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
MDA-MB-453 cell breast cancer cell Homo sapiens
-
MDA-MB-468 cell
-
 Homo sapiens
-
SK-BR-3 cell breast cancer cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1 Homo sapiens ?
-
 ?
UDP-GlcNAc + transcription factor FoxM1
-
 Homo sapiens O-GlcNAc-transcription factor FoxM1 + UDP
-
 ?

Synonyms

Synonyms Comment Organism
O-GlcNAc transferase
-
 Homo sapiens
OGT
-
 Homo sapiens