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Literature summary for 2.4.1.255 extracted from

  • Martinez-Fleites, C.; Macauley, M.S.; He, Y.; Shen, D.L.; Vocadlo, D.J.; Davies, G.J.
    Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation (2008), Nat. Struct. Mol. Biol., 15, 764-765.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Xanthomonas campestris

Protein Variants

Protein Variants Comment Organism
D925A active site mutant Homo sapiens
H558A active site mutant Homo sapiens
H558D active site mutant Homo sapiens
H558E active site mutant Homo sapiens
H901Y active site mutant Homo sapiens
H920A active site mutant, deleterious Homo sapiens
K842A active site mutant, low specific activity Homo sapiens
K898A active site mutant, Lys898, which is involved in uracil binding, mutation results in a protein with no apparent activity Homo sapiens
Q839E active site mutant Homo sapiens
Q839N active site mutant, low specific activity Homo sapiens
T921A active site mutant, 18% activity compared to wild-type Homo sapiens
Y841A active site mutant, lowers specific activity to 24% compared to wild-type Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
UDP inhibits by excess Xanthomonas campestris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme catalyzes O-GlcNAc addition ?
-
?
additional information Xanthomonas campestris enzyme catalyzes O-GlcNAc addition ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Xanthomonas campestris
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme catalyzes O-GlcNAc addition Homo sapiens ?
-
?
additional information enzyme catalyzes O-GlcNAc addition Xanthomonas campestris ?
-
?
UDP-N-acetyl-D-glucosamine + [protein]-L-serine
-
Xanthomonas campestris UDP + [protein]-O3-(N-acetyl-D-glucosaminyl)-L-serine
-
?
UDP-N-acetyl-D-glucosamine + [protein]-L-threonine
-
Xanthomonas campestris UDP + [protein]-O3-(N-acetyl-D-glucosaminyl)-L-threonine
-
?

Synonyms

Synonyms Comment Organism
glycosyltransferase OGT
-
Homo sapiens
glycosyltransferase OGT
-
Xanthomonas campestris
HsOGT
-
Homo sapiens
human OGT
-
Homo sapiens
O-GlcNAc transferase
-
Homo sapiens
O-GlcNAc transferase
-
Xanthomonas campestris
OGT
-
Homo sapiens
OGT
-
Xanthomonas campestris
UDP-GlcNAc:polypeptidyl transferase
-
Homo sapiens
UDP-GlcNAc:polypeptidyl transferase
-
Xanthomonas campestris
XcOGT
-
Xanthomonas campestris