Literature summary for 2.4.1.255 extracted from

Roos, M.D.; Hanover, J.A.
Structure of O-linked GlcNAc transferase: Mediator of glycan-dependent signaling (2000), Biochem. Biophys. Res. Commun., 271, 275-280.

Search for more literature for 2.4.1.255

Crystallization (Commentary)

Crystallization (Comment)	Organism
three-dimensional structure of the protein domains I and II, conserved amino acid sequences	Homo sapiens
three-dimensional structure of the protein domains I and II, conserved amino acid sequences	Arabidopsis thaliana
three-dimensional structure of the protein domains I and II, conserved amino acid sequences	Rhodobacter sp.

Protein Variants

Protein Variants	Comment	Organism
additional information	deletional or disrupting mutation of the Spindly SPY locus affects the enzyme and the plant signaling, e.g. increased gibberillin signaling, altered phenotypes	Arabidopsis thaliana

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Arabidopsis thaliana	5829	-
cytosol	-	Rhodobacter sp.	5829	-
nucleus	-	Homo sapiens	5634	-
nucleus	-	Arabidopsis thaliana	5634	-
nucleus	-	Rhodobacter sp.	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rhodobacter sp.	enzyme adds a single GlcNAc to hydroxyl groups of serine and threonine residues	?	-	?
additional information	Arabidopsis thaliana	enzyme adds a single GlcNAc to hydroxyl groups of serine and threonine residues. In the plant Arabidopsis, OGT serves to attenuate the gibberillin pathway	?	-	?
additional information	Homo sapiens	enzyme adds a single GlcNAc to hydroxyl groups of serine and threonine residues. Substrates are many proteins, e.g. transcription factors, kinases, cytoskeletal proteins, and nuclear pore proteins	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	-	-
Homo sapiens	-	-	-
no activity in Escherichia coli	-	-	-
no activity in Saccharomyces cerevisiae	-	-	-
Rhodobacter sp.	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme adds a single GlcNAc to hydroxyl groups of serine and threonine residues	Rhodobacter sp.	?	-	?
additional information	enzyme adds a single GlcNAc to hydroxyl groups of serine and threonine residues. In the plant Arabidopsis, OGT serves to attenuate the gibberillin pathway	Arabidopsis thaliana	?	-	?
additional information	enzyme adds a single GlcNAc to hydroxyl groups of serine and threonine residues. Substrates are many proteins, e.g. transcription factors, kinases, cytoskeletal proteins, and nuclear pore proteins	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
More	three-dimensional structure of the protein domains I and II, conserved amino acid sequences	Homo sapiens
More	three-dimensional structure of the protein domains I and II, conserved amino acid sequences	Arabidopsis thaliana
More	three-dimensional structure of the protein domains I and II, conserved amino acid sequences	Rhodobacter sp.

Synonyms

Synonyms	Comment	Organism
nucleocytoplasmic glycosyltransferase	-	Homo sapiens
nucleocytoplasmic glycosyltransferase	-	Arabidopsis thaliana
nucleocytoplasmic glycosyltransferase	-	Rhodobacter sp.
O-linked GlcNAc transferase	-	Homo sapiens
O-linked GlcNAc transferase	-	Arabidopsis thaliana
O-linked GlcNAc transferase	-	Rhodobacter sp.
OGT	-	Homo sapiens
OGT	-	Arabidopsis thaliana
OGT	-	Rhodobacter sp.
SPY	-	Arabidopsis thaliana

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)