Organism | UniProt | Comment | Textmining |
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Corynebacterium glutamicum | Q8NTA6 | - |
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Corynebacterium glutamicum DSM 20300 | Q8NTA6 | - |
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General Information | Comment | Organism |
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physiological function | overexpression of the gene, MshA, coding for mycothiol glycosyl transferase improves the robustness of Corynebacterium glutamicum to various stresses. Intracellular mycothiol content is increased by 114% upon overexpression of MshA. Survival rates increased by 44, 39, 90, 77, 131, 87, 52, 47, 57, 85 and 33% as compared to wild-type under stress by H2O2 (40 mM), methylglyoxal (5.8 mM), erythromycin (0.08 mg/ml), streptomycin (0.005 mg/ml), Cd2+ (0.01 mM), Mn2+ (2 mM), formic acid (0.05%), acetic acid (0.15%), levulinic acid (0.25%), furfural (7.2 mM), and ethanol (10% v/v), respectively. Increased mycothiol content also decreases the concentration of reactive oxygen species in the presence of the above stresses | Corynebacterium glutamicum |