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Literature summary for 2.4.1.250 extracted from
- The mshA gene encoding the glycosyltransferase of mycothiol biosynthesis is essential in Mycobacterium tuberculosis Erdman (2006), FEMS Microbiol. Lett., 264, 74-79.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| construction of Mycobacterium tuberculosis with two copies of mshA | Mycobacterium tuberculosis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate | Mycobacterium tuberculosis | 1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, the mshA gene is essential for the growth of Mycobacterium tuberculosis | 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP | - |
? |  |
| UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate | Mycobacterium tuberculosis Erdman | 1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, the mshA gene is essential for the growth of Mycobacterium tuberculosis | 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
Erdman | - |
| Mycobacterium tuberculosis Erdman | - |
Erdman | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| UDP-N-acetyl-alpha-D-glucosamine + 1D-myo-inositol 3-phosphate = 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP | 1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate | Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate | 1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, the mshA gene is essential for the growth of Mycobacterium tuberculosis | Mycobacterium tuberculosis | 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP | - |
? | |
| UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate | 1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate | Mycobacterium tuberculosis | 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP | - |
? | |
| UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate | 1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, the mshA gene is essential for the growth of Mycobacterium tuberculosis | Mycobacterium tuberculosis Erdman | 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP | - |
? | |
| UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate | 1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate | Mycobacterium tuberculosis Erdman | 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP | - |
? | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | inability to disrupt the mshA gene in Mycobacterium tuberculosis containing a single copy of mshA. Directed knock-out of the mshA gene in Mycobacterium tuberculosis Erdman is only possible when a second copy of mshA is first incorporated into the chromosome. Bacteria with only a single copy of mshA that grew after mutagenesis produced normal levels of mycothiol | Mycobacterium tuberculosis |
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