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Literature summary for 2.4.1.244 extracted from
- beta1,4-N-acetylgalactosaminyltransferase III modulates cancer stemness through EGFR signaling pathway in colon cancer cells (2014), Oncotarget, 5, 3673-3684.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene B4GALNT3 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | B4GALNT3 overexpression enhances colon cancer cell malignant phenotypes in vitro and in vivo. Knockdown of B4GALNT3 using small interfering (si) RNAs in colon cancer cell lines (HCT116, SW480, HCT15, and HT29 cells) decrease sphere formation and the expression of stem cell markers, OCT4 and. NANOG. B4GALNT3 knockdown suppresses EGF-induced phosphorylation of epithelial growth factor receptor, EGFR, and its downstream signaling molecules | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q6L9W6 | gene B4GALNT3 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colon | mainly expressed in | Homo sapiens | - |
| colon cancer cell | primary, B4GALNT3 expression in different stage of colorectal tumors, overview | Homo sapiens | - |
| epithelial cell | high enzyme expression level in epithelial cells of gastric mucosa | Homo sapiens | - |
| gastric mucosa | - |
Homo sapiens | - |
| HCT-116 cell | - |
Homo sapiens | - |
| HCT-15 cell | - |
Homo sapiens | - |
| HT-29 cell | - |
Homo sapiens | - |
| stomach | mainly expressed in | Homo sapiens | - |
| SW-480 cell | - |
Homo sapiens | - |
| testis | mainly expressed in | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme B4GALNT3 primarily modifies N-glycans of epithelial growth factor receptor, EGFR, in LacdiNAc by Wisteria floribunda agglutinin pull down assays | Homo sapiens | ? | - |
? |  |
| UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosamine | enzyme B4GALNT3 transfers N-acetylgalactosamine (GalNAc) to the non-reducing N-acetylglucosamine (GlcNAc) to form GalNAcbeta1-4GlcNAc (LacdiNAc) in an in vitro enzymatic assay | Homo sapiens | UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosamine | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group | - |
Homo sapiens | UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| B4GALNT3 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | expression of B4GALNT3 is regulated in colonospheres | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | B4GALNT3 overexpression enhances colon cancer cell malignant phenotypes in vitro and in vivo. B4GALNT3 knockdown suppresses EGF-induced phosphorylation of epithelial growth factor receptor, EGFR, and its downstream signaling molecules. B4GALNT3 knockdown inhibits EGFR activity, decreases EGF-induced migration and invasion in colon cancer cells, and promotes EGFR degradation in colon cancer cells, overview | Homo sapiens |
| physiological function | beta1,4-N-acetylgalactosaminyltransferase III modulates cancer stemness through EGFR signaling pathway in colon cancer cells, B4GALNT3 regulates cancer stemness and the invasive properties of colon cancer cells through modifying EGFR glycosylation and signaling. B4GALNT3 expression is positively correlated with advanced stages and poor survival in colorectal cancer patients | Homo sapiens |
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