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Literature summary for 2.4.1.244 extracted from

  • Sasaki, N.; Yoshida, H.; Fuwa, T.J.; Kinoshita-Toyoda, A.; Toyoda, H.; Hirabayashi, Y.; Ishida, H.; Ueda, R.; Nishihara, S.
    Drosophila beta1,4-N-acetylgalactosaminyltransferase-A synthesizes the LacdiNAc structures on several glycoproteins and glycosphingolipids (2007), Biochem. Biophys. Res. Commun., 354, 522-527.
    View publication on PubMed
Search for more literature for 2.4.1.244

Cloned(Commentary)

Cloned (Comment) Organism
expressed in sf21 cells Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl-R group Drosophila sp. (in: flies) beta4GalNAcTA contributs to the synthesis of the GalNAcbeta1,4GlcNA structure in vivo and may play a role in the physiological or neuronal development of Drosophila UDP + N-acetyl-beta-D-galactosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl-R group
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 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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Drosophila sp. (in: flies)
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Purification (Commentary)

Purification (Comment) Organism
anti-FLAG M1 affinity gel filtration Drosophila melanogaster

Source Tissue

Source Tissue Comment Organism Textmining
embryo beta4GalNAcT mRNA is expressed throughout the life cycle of the fly, i.e., from the embryo stage. In the larval stage, mRNA is expressed to a greater extent in the eye disc and larval brain than in the wing disc and leg disc Drosophila sp. (in: flies)
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larva beta4GalNAcT mRNA is expressed throughout the life cycle of the fly, i.e., from the embryo stage. In the larval stage, mRNA is expressed to a greater extent in the eye disc and larval brain than in the wing disc and leg disc Drosophila sp. (in: flies)
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neuron highly expressed in the developmental and adult neuronal tissues Drosophila sp. (in: flies)
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity with GalNac Drosophila melanogaster ?
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 ?
UDP-GalNAc + GlcNAc-beta-(1,2)-Man-alpha-(1,6)-[Gal-beta-(1,4)-GlcNAc-beta-(1,2)-Man-alpha-(1,3)]Man-beta-(1,4)-GlcNAc-beta-(1,4)-[Fuc-alpha-(1,6)]-GlcNAc-2-pyridylaminoside
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 Drosophila melanogaster UDP + GalNAc-beta-(1,4)-GlcNAc-beta-(1,2)-Man-alpha-(1,6)-[Gal-beta-(1,4)-GlcNAc-beta-(1,2)-Man-alpha-(1,3)]Man-beta-(1,4)-[Fuc-alpha-(1,6)]-GlcNAc-beta-(1,4)-GlcNAc-2-pyridylaminoside
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 ?
UDP-GalNAc + GlcNAc-beta-(1,3)-GalNAc-alpha-p-nitrophenyl
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 Drosophila melanogaster UDP + GalNAc-beta-(1,4)-GlcNAc-beta-(1,3)-GalNAc-alpha-p-nitrophenyl
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 ?
UDP-GalNAc + GlcNAc-beta-(1,3)Fuc-dansyl
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 Drosophila melanogaster UDP + GalNAc-beta-(1,4)-GlcNAc-beta-(1,3)Fuc-dansyl
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 ?
UDP-N-acetyl-D-galactosamine + GlcNAcbeta1,2Manalpha1,6[GlcNAcbeta1,2Manalpha1,3]Manbeta1,4GlcNAcbeta1,4GlcNAc-aminopyridine
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 Drosophila sp. (in: flies) ?
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 ?
UDP-N-acetyl-D-galactosamine + GlcNAcbeta1,2Manalpha1,6[GlcNAcbeta1,4[GlcNAcbeta1,2]Manalpha1,3]Manbeta1,4GlcNAcbeta1,4GlcNAc-aminopyridine
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 Drosophila sp. (in: flies) ?
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 ?
UDP-N-acetyl-D-galactosamine + GlcNAcbeta1,3Fuc-dansyl GalNAc is efficiently transferred toward N-glycans, O-glycans, and the arthro-series glycosphingolipids Drosophila sp. (in: flies) ?
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 ?
UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl-R group beta4GalNAcTA contributs to the synthesis of the GalNAcbeta1,4GlcNA structure in vivo and may play a role in the physiological or neuronal development of Drosophila Drosophila sp. (in: flies) UDP + N-acetyl-beta-D-galactosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl-R group
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 ?

Synonyms

Synonyms Comment Organism
beta 1,4-N-acetylgalactosaminyltransferase-A
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 Drosophila melanogaster
beta1,4-N-acetylgalactosaminyltransferase
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 Drosophila sp. (in: flies)
beta4GalNAcT
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 Drosophila melanogaster
beta4GalNAcT
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 Drosophila sp. (in: flies)